The E and Z isomeric intermediates based on ethyl/methyl-2-cyano-3-(5-formyl-1-(4-iodo-phenyl)-1H-pyrrol-2-yl)acrylate have been synthesized and these intermediates (E or Z) were further stereo-selectively converted into their respective E, E or E, Z isomers of diethyl/dimethyl-3,3'-(1-(4-iodophenyl)-1H-pyrrole-2,5-diyl)bis (2-cyanoacrylate) at the first time. The E, E isomers of both 2a and 3a, in solid state displayed higher quantum efficiency with longer fluorescent lifetime as compared to E, Z isomers. Notably, the E, E isomers proved to be better AIEs while, E, Z isomer of 2a has eminent anticancer activity against human nasopharyngeal carcinoma. A simple and straight forward strategy has been firstly developed to utilize the impact of configuration on fluorescence and anti-cancer activity.

合成了基于乙基/甲基-2-氰基-3-（5-甲酰基-1-（4-碘-苯基）-1H-吡咯-2-基）丙烯酸酯的E和Z异构中间体，这些中间体（E或Z）进一步立体选择性地转化为二乙基/二甲基-3,3'-（1-（4-碘苯基）-1H-吡咯-2,5-二基）双的各自的E，E或E，Z异构体（2-氰基丙烯酸酯）。与E，Z异构体相比，固态的2a和3a的E，E异构体显示出更高的量子效率和更长的荧光寿命。值得注意的是，E，E异构体被证明是更好的AIE，而2a的E，Z异构体对人鼻咽癌具有显着的抗癌活性。首先开发了一种简单明了的策略，以利用构型对荧光和抗癌活性的影响。