Oxidase-like MOF-818 Nanozyme with High Specificity for Catalysis of Catechol Oxidation,Journal of the American Chemical Society

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Oxidase-like MOF-818 Nanozyme with High Specificity for Catalysis of Catechol Oxidation
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-08-13 , DOI: 10.1021/jacs.0c07273
Minghua Li _{1,

2} , Jinxing Chen _{2,

3} , Weiwei Wu _{2,

3} , Youxing Fang ₂ , Shaojun Dong _{1,

2,

3}

Affiliation

Despite the extensive studies of the nanozymes showing their superior properties compared to natural enzymes and traditional artificial enzymes, the development of highly specific nanozymes is still a challenge. The catechol oxidase specifically catalyzing the oxidations of o-diphenol to the corresponding o-quinone is important to the biosynthesis of melanin and other polyphenolic natural products. In this study, we firstly propose that MOF-818, containing trinuclear copper centers mimicking the active sites of natural catechol oxidase, shows the efficient catechol oxidase activity with good specificity and no peroxidase-like characteristics. MOF-818 has good specificity and high catalytic activity as a novel catechol oxidase nanozyme.

中文翻译：

具有高特异性催化邻苯二酚氧化的氧化酶样MOF-818纳米酶

尽管对纳米酶的广泛研究表明与天然酶和传统人工酶相比具有优越的特性，但高度特异性的纳米酶的开发仍然是一个挑战。儿茶酚氧化酶特异性催化邻二酚氧化成相应的邻醌，对黑色素和其他多酚天然产物的生物合成很重要。在这项研究中，我们首先提出 MOF-818 含有模拟天然儿茶酚氧化酶活性位点的三核铜中心，显示出高效的儿茶酚氧化酶活性，具有良好的特异性，没有过氧化物酶样特征。MOF-818 作为一种新型儿茶酚氧化酶纳米酶，具有良好的特异性和高催化活性。

更新日期：2020-08-13

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