Co-Axial Fibers with Janus-Structured Sheaths by Electrospinning Release Corn Peptides for Wound Healing,ACS Applied Bio Materials

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Co-Axial Fibers with Janus-Structured Sheaths by Electrospinning Release Corn Peptides for Wound Healing
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-08-13 , DOI: 10.1021/acsabm.0c00860
Xuan Ji ₁ , Rui Li ₂ , Wenyuan Jia ₃ , Guomin Liu ₃ , Yungang Luo ₁ , Zhiqiang Cheng ₂

Affiliation

Delayed wound healing in skin is strongly correlated with excessive reactive oxygen species (ROS) generation. Corn peptides (CPs) have robust antioxidant and anti-inflammatory effects. Therefore, the study sought to evaluate the wound healing effect of topical application of CPs embedded in wound dressings fabricated using the coaxial electrospinning technique. A special structure, which was a co-axial structure with a Janus-structured sheath, was displayed on the fiber. The fibers exhibited stable thermal properties, suitable tensile properties, high wettability, excellent biocompatibility, and free radical scavenging capability. Additionally, a first-order release profile of CPs from the fibers showed that approximately 92% of the drug was released within 80 min. In vivo experiments indicated that CPs-loaded fibrous membranes significantly improved the wound healing ratio, thickened the re-epithelialization layer, enhanced fibroblast proliferation, and increased the production of regenerated hair follicles and capillaries. Overall, it is promising that the combination of CPs and fibrous membranes with special structures applies in skin tissue engineering to promote wound repair.

中文翻译：

具有 Janus 结构护套的同轴纤维通过静电纺丝释放玉米肽用于伤口愈合

皮肤伤口愈合延迟与过量的活性氧 (ROS) 生成密切相关。玉米肽 (CPs) 具有强大的抗氧化和抗炎作用。因此，该研究旨在评估局部应用嵌入使用同轴静电纺丝技术制造的伤口敷料中的 CP 的伤口愈合效果。在光纤上展示了一种特殊的结构，它是一种带有 Janus 结构护套的同轴结构。纤维表现出稳定的热性能、合适的拉伸性能、高润湿性、优异的生物相容性和自由基清除能力。此外，纤维中 CP 的一级释放曲线表明，大约 92% 的药物在 80 分钟内释放。体内实验表明，负载CPs的纤维膜显着提高了伤口愈合率，增厚了再上皮化层，增强了成纤维细胞的增殖，并增加了再生毛囊和毛细血管的产生。总体而言，CPs与具有特殊结构的纤维膜的结合应用于皮肤组织工程以促进伤口修复是有希望的。

更新日期：2020-09-21

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