婴儿期发育迟缓、青春期轨迹和成人身体成分：南非出生至 20 岁以上人群。,European Journal of Clinical Nutrition

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婴儿期发育迟缓、青春期轨迹和成人身体成分：南非出生至 20 岁以上人群。
European Journal of Clinical Nutrition ( IF 3.6 ) Pub Date : 2020-08-14 , DOI: 10.1038/s41430-020-00716-1
Glory Chidumwa ₁ , Rihlat Said-Mohamed _{1,

2} , Lukhanyo H Nyati ₁ , Feziwe Mpondo ₁ , Tinashe Chikowore ₁ , Alessandra Prioreschi ₁ , Juliana Kagura _{1,

3} , Lisa J Ware ₁ , Lisa K Micklesfield ₁ , Shane A Norris _{1,

4}

Affiliation

背景/目标

儿童期的快速成长和青春期提前与成人肥胖有关。然而，儿童发育迟缓、青春期时机和成人肥胖之间的关联尚不清楚。我们使用 Birth-to-20 Plus 队列（南非）检查了 2 岁 (y) 发育迟缓与 23 岁身体成分之间的关系是否由青少年体重指数和青春期发育介导。

科目/方法

对于 1036 名参与者，收集了出生至 23 岁之间的人体测量学数据、母亲因素和青春期发育（9-16 岁的坦纳量表）。2 岁时发育迟缓（年龄别身高z分数 < -2）、5-18 岁年龄别体重指数轨迹、青春期发育轨迹以及 DXA 衍生的脂肪量 (FM) 和无脂肪量 (FFM)确定了23年。使用分层回归和结构方程模型分析数据。

结果

发育迟缓与青春期发育较慢和成年身高较短直接相关，但与青少年 BMI 轨迹、成人 FM 或 FFM 无关。然而，发育迟缓与成人 FM 和 FFM 间接相关，因为青春期发育较慢与 FM 较低之间以及身高较短与 FFM 较低之间存在直接关联。BMI 轨迹与 FM 和 FFM 独立相关。

结论

在这个人群中发育迟缓通过较慢的青春期发育和较短的成年身高来预测成人的身体成分。

"点击查看英文标题和摘要"

Stunting in infancy, pubertal trajectories and adult body composition: the Birth to Twenty Plus cohort, South Africa.

Background/objectives

Childhood rapid growth and earlier puberty onset have been associated with adult obesity. However, the association between childhood stunting, pubertal timing and adult obesity is unclear. We examined whether the relationship between stunting at age 2 years (y) and body composition at 23 years is mediated by adolescent body mass index, and pubertal development, using the Birth-to-Twenty Plus cohort (South Africa).

Subjects/methods

For 1036 participants, data on anthropometrics between birth and 23 years, maternal factors, and pubertal development (Tanner scale at 9–16 years) were collected. Stunting at 2 years (height-for-age z-score < −2), 5–18 years BMI-for-age trajectories, pubertal development trajectories, and DXA-derived fat mass (FM) and fat free mass (FFM) at 23 years were determined. Data were analysed using hierarchical regressions and structural equation models.

Results

Stunting was directly associated with slower pubertal development and with shorter adult stature, but was not associated with adolescent BMI trajectories, adult FM or FFM. However, stunting was indirectly associated with adult FM and FFM through the direct associations between slower pubertal development and lower FM and between shorter height and lower FFM. BMI trajectories were independently associated with FM and FFM.