当前位置: X-MOL 学术Tetrahedron Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-08-14 , DOI: 10.1016/j.tetlet.2020.152320
Youming Huang , Hongyi Chen , Wenting Zheng , Qingle Zeng

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).



中文翻译:

Cu 2 O催化的季铵盐与链烷烃/亚芳基亚磺酸钠的C–S偶联

已经开发了一种新的协议,该协议通过烷烃/芳烃亚​​磺酸盐和(对映体富集的)苄基季铵盐的Cu 2 O催化的C–S键交叉偶联来合成(对映体富集的)苄基砜。获得的苄基砜产品收率良好至高(75-96%)。在Cu 2 O和1,1'-双-(二苯基膦基)二茂铁(dppf)存在下,还合成了具有高对映体过量(90-94%ee)的手性芳基甲基砜。

更新日期:2020-09-03
down
wechat
bug