可生物吸收的可植入医疗器械综述：材料，制造和实施。,Advanced Healthcare Materials

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可生物吸收的可植入医疗器械综述：材料，制造和实施。
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-08-12 , DOI: 10.1002/adhm.202000790
Rahul Singh ₁ , Mohammad Javad Bathaei ₂ , Emin Istif ₁ , Levent Beker ₁

Affiliation

植入式医疗设备（IMD）旨在感应特定参数或刺激器官，并已被积极用于各种疾病的治疗和诊断。IMD用于长期疾病筛查或治疗，不能用于短期应用，因为患者需要进行手术以取回IMD。生物可吸收材料的进步导致了瞬态IMD的发展，这些IMD可以被体液吸收并在一定时期后消失。这些设备被设计为在预定时间被植入目标组织附近，目的是测量压力，应变或温度，而生物电子设备则刺激某些组织。它们为监测和治疗急性疾病提供了机会。为了实现这种瞬态和小型化设备，研究人员利用了多种材料，新颖的制造方法和设备设计策略。这篇综述讨论了IMD中每个成分的潜在生物可吸收材料，以及可编程的降解和安全标准。然后，介绍了生物可吸收材料的常见制造方法以及挑战。最后一部分提供了各种用途的生物可吸收IMD的代表性示例，重点是材料，设备功能和制造方法。介绍了生物可吸收材料的常见制造方法以及挑战。最后一部分提供了各种用途的生物可吸收IMD的代表性示例，重点是材料，设备功能和制造方法。介绍了生物可吸收材料的常见制造方法以及挑战。最后一部分提供了各种用途的生物可吸收IMD的代表性示例，重点是材料，设备功能和制造方法。

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A Review of Bioresorbable Implantable Medical Devices: Materials, Fabrication, and Implementation.

Implantable medical devices (IMDs) are designed to sense specific parameters or stimulate organs and have been actively used for treatment and diagnosis of various diseases. IMDs are used for long‐term disease screening or treatments and cannot be considered for short‐term applications since patients need to go through a surgery for retrieval of the IMD. Advances in bioresorbable materials has led to the development of transient IMDs that can be resorbed by bodily fluids and disappear after a certain period. These devices are designed to be implanted in the adjacent of the targeted tissue for predetermined times with the aim of measurement of pressure, strain, or temperature, while the bioelectronic devices stimulate certain tissues. They enable opportunities for monitoring and treatment of acute diseases. To realize such transient and miniaturized devices, researchers utilize a variety of materials, novel fabrication methods, and device design strategies. This review discusses potential bioresorbable materials for each component in an IMD followed by programmable degradation and safety standards. Then, common fabrication methods for bioresorbable materials are introduced, along with challenges. The final section provides representative examples of bioresorbable IMDs for various applications with an emphasis on materials, device functionality, and fabrication methods.

更新日期：2020-09-23

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