<br>快速眼动睡眠与认知健康的老年人的白质完整性有关。,PLOS ONE

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快速眼动睡眠与认知健康的老年人的白质完整性有关。
PLOS ONE ( IF 2.9 ) Pub Date : 2020-07-09 , DOI: 10.1371/journal.pone.0235395
Marie Altendahl ₁ , Devyn L Cotter ₁ , Adam M Staffaroni ₁ , Amy Wolf ₁ , Paige Mumford ₁ , Yann Cobigo ₁ , Kaitlin Casaletto ₁ , Fanny Elahi ₁ , Leslie Ruoff ₂ , Samirah Javed _{1,

3} , Brianne M Bettcher _{1,

4} , Emily Fox ₁ , Michelle You ₁ , Rowan Saloner ₁ , Thomas C Neylan _{1,

2,

3} , Joel H Kramer _{1,

3} , Christine M Walsh ₁

Affiliation

人们越来越认识到，老年人自我报告的睡眠异常与大脑结构和功能呈负相关。然而，人们对于客观测量的睡眠与大脑结构之间的关系知之甚少。我们客观地测量了家庭睡眠，以研究老年人的睡眠结构和睡眠质量与白质微结构的关系。 43 名认知正常的老年人在六个月内接受了弥散张量成像 (DTI) 和睡眠评估。参与者完成了 PSQI（睡眠质量的主观测量），并使用家用睡眠记录仪 (Zeo, Inc.) 测量总睡眠时间 (TST)、睡眠效率 (SE) 和浅睡眠时间百分比 (LS) 、深度睡眠 (DS) 和快速眼动睡眠 (RS)。多元回归预测胼胝体的分数各向异性 (FA) 和平均扩散率 (MD) 作为 PSQI 总分、TST、SE 和每个睡眠阶段花费的时间百分比的函数，并控制年龄和性别。 RS 花费的时间百分比越大，与较高的 FA（β = 0.41，p = 0.007）和较低的 MD（β = -0.30，p = 0.03）显着相关。 PSQI 总分、TST、SE 以及 LS 或 DS 花费的时间与 FA 或 MD 没有显着相关性 (p>0.13)。快速眼动睡眠所花费的时间百分比，但不是浅睡眠和深睡眠的数量或睡眠质量的主观/客观测量，可以积极预测白质微观结构的完整性。我们的研究结果强调了快速眼动睡眠和大脑健康之间的重要联系，有可能改善老年人的睡眠干预。

"点击查看英文标题和摘要"

REM sleep is associated with white matter integrity in cognitively healthy, older adults.

There is increasing awareness that self-reported sleep abnormalities are negatively associated with brain structure and function in older adults. Less is known, however, about how objectively measured sleep associates with brain structure. We objectively measured at-home sleep to investigate how sleep architecture and sleep quality related to white matter microstructure in older adults. 43 cognitively normal, older adults underwent diffusion tensor imaging (DTI) and a sleep assessment within a six-month period. Participants completed the PSQI, a subjective measure of sleep quality, and used an at-home sleep recorder (Zeo, Inc.) to measure total sleep time (TST), sleep efficiency (SE), and percent time in light sleep (LS), deep sleep (DS), and REM sleep (RS). Multiple regressions predicted fractional anisotropy (FA) and mean diffusivity (MD) of the corpus callosum as a function of total PSQI score, TST, SE, and percent of time spent in each sleep stage, controlling for age and sex. Greater percent time spent in RS was significantly associated with higher FA (β = 0.41, p = 0.007) and lower MD (β = -0.30, p = 0.03). Total PSQI score, TST, SE, and time spent in LS or DS were not significantly associated with FA or MD (p>0.13). Percent time spent in REM sleep, but not quantity of light and deep sleep or subjective/objective measures of sleep quality, positively predicted white matter microstructure integrity. Our results highlight an important link between REM sleep and brain health that has the potential to improve sleep interventions in the elderly.

更新日期：2020-07-09

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