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[A new antiviral isoquinoline alkaloid from Thalictrum glandulosissimum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Pub Date : 2020-06-01 , DOI: 10.19540/j.cnki.cjcmm.20200229.203
Dian Luo 1 , Na Lyu 1 , Ling-Min Liao 1 , Qian Gao 2 , Yin-Ke Li 1 , Jing Li 2 , Xin Liu 2 , Xue-Mei Li 2 , Guang-Yu Yang 1 , Yan-Qing Ye 3 , Qiu-Fen Hu 1 , Miao Dong 3
Affiliation  

A new isoquinoline alkaloid(1) has been isolated from the whole plant of Thalictrum glandulosissimum by using various chromatographic techniques, including silica gel, sephadex, MCI-gel resin, and RP-HPLC, and its structure was determined as 1-(6-hydroxy-7-methylisoquinolin-1-yl) ethantone by physicochemical properties and spectroscopic data. This compound was evaluated for anti-tobacco mosaic virus(TMV) activity. The results showed that it had prominent anti-TMV activity with inhibition rates of 28.4%. This rate was closed to that of positive control.

中文翻译:

拟南芥中一种新的抗病毒异喹啉生物碱

利用硅胶,sephadex,MCI-gel树脂,RP-HPLC等多种色谱技术从拟南芥的整个植物中分离到一种新的异喹啉生物碱(1),其结构确定为1-(6-羟基七甲基异喹啉-1-基)乙酮的理化性质和光谱数据。评价该化合物的抗烟草花叶病毒(TMV)活性。结果表明,它具有显着的抗TMV活性,抑制率为28.4%。该比率接近于阳性对照。
更新日期:2020-06-01
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