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Preparation of phenylboronic acid‐based hydrogel microneedle patches for glucose‐dependent insulin delivery
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-08-12 , DOI: 10.1002/app.49772 Xiang Chen 1 , Haojie Yu 1 , Li Wang 1 , Nan Wang 1 , Qian Zhang 2 , Weibin Zhou 2 , Md Alim Uddin 1
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-08-12 , DOI: 10.1002/app.49772 Xiang Chen 1 , Haojie Yu 1 , Li Wang 1 , Nan Wang 1 , Qian Zhang 2 , Weibin Zhou 2 , Md Alim Uddin 1
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There is a problem with directly loading insulin into the polymerized glucose‐responsive microneedle (MN) patch due to that polymerization conditions and solvents may damage the activity of insulin. In this study, we report a totally polymerized phenylboronic acid‐based MN patch, and insulin was directly loaded in MNs by a mild drop/dry procedure. MN patch was prepared by copolymerization of N ‐isopropyl acrylamide, N ‐vinyl‐2‐pyrrolidone, and 3‐acrylamidoephenylboronic acid in MN mold. The MN patch showed good glucose‐dependent swelling behavior in pH 9.0 at 27°C. After insulin loading procedure, insulin was distributed on and within the MNs. About 43.2% of total insulin was diffused into MNs' interior. As a result, the release of insulin on MNs' surface was uncontrolled by MNs and rapidly finished after ~10 min. However, the release of insulin within MNs was depended on glucose concentration, and insulin was released 1.6 times more at 4 g/L than at 1 g/L glucose concentration after 12 h. Although further improvements are needed to make MN patch responding in physiological environment, this work suggests a solution for directly loading insulin in polymerized glucose‐responsive MNs.
中文翻译：
制备基于苯硼酸的水凝胶微针贴剂，用于葡萄糖依赖的胰岛素输送
直接将胰岛素加载到聚合的葡萄糖反应性微针（MN）贴剂中存在一个问题，因为聚合条件和溶剂可能会破坏胰岛素的活性。在这项研究中，我们报道了完全聚合的基于苯硼酸的MN贴剂，并且通过温和的滴/干程序将胰岛素直接负载在MN中。MN贴剂是通过共聚N-异丙基丙烯酰胺，NMN模具中有乙烯基2-吡咯烷酮和3-丙烯酰胺基苯硼酸 MN贴片在27°C的pH 9.0下表现出良好的葡萄糖依赖性溶胀行为。胰岛素加载程序后，胰岛素在MN上和内分布。总胰岛素中约有43.2％扩散到MN的内部。结果，MNs不能控制MNs表面的胰岛素释放，并且在大约10分钟后迅速结束。但是，MNs中胰岛素的释放取决于葡萄糖浓度，在12 g后，在4 g / L时，胰岛素的释放比1 g / L时高1.6倍。尽管需要进一步的改进以使MN贴片在生理环境中做出反应，但这项工作提出了一种将胰岛素直接负载在聚合的葡萄糖反应性MN中的解决方案。
更新日期：2020-08-12
中文翻译：
制备基于苯硼酸的水凝胶微针贴剂，用于葡萄糖依赖的胰岛素输送
直接将胰岛素加载到聚合的葡萄糖反应性微针（MN）贴剂中存在一个问题，因为聚合条件和溶剂可能会破坏胰岛素的活性。在这项研究中，我们报道了完全聚合的基于苯硼酸的MN贴剂，并且通过温和的滴/干程序将胰岛素直接负载在MN中。MN贴剂是通过共聚N-异丙基丙烯酰胺，NMN模具中有乙烯基2-吡咯烷酮和3-丙烯酰胺基苯硼酸 MN贴片在27°C的pH 9.0下表现出良好的葡萄糖依赖性溶胀行为。胰岛素加载程序后，胰岛素在MN上和内分布。总胰岛素中约有43.2％扩散到MN的内部。结果，MNs不能控制MNs表面的胰岛素释放，并且在大约10分钟后迅速结束。但是，MNs中胰岛素的释放取决于葡萄糖浓度，在12 g后，在4 g / L时，胰岛素的释放比1 g / L时高1.6倍。尽管需要进一步的改进以使MN贴片在生理环境中做出反应，但这项工作提出了一种将胰岛素直接负载在聚合的葡萄糖反应性MN中的解决方案。
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