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Copper catalysis: One-pot simultaneous synthesis of quinolines and gem-diamine derivatives
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-08-12 , DOI: 10.1016/j.tetlet.2020.152346
Xing-Meng Li , Li Tang , Zhu-Ming Qian , Yan-Hong He , Zhi Guan

A copper(II)-catalyzed oxidative reaction for the one-pot simultaneous synthesis of quinolines and gem-diamine derivatives from N-arylglycine ethyl esters and enamides is described. In this reaction, the two fragments in an enamide substrate react with the same intermediate generated in situ from an N-arylglycine ethyl ester, respectively, producing two products simultaneously. This reaction has the advantages of high efficiency, simple operation and high atom economy.



中文翻译:

铜催化:一锅同时合成喹啉和宝石-二胺衍生物

的铜(II)催化的对喹啉和的一锅同时合成的氧化反应宝石从二胺衍生物N-芳基甘氨酸乙基酯和烯酰胺进行说明。在该反应中,酰胺底物中的两个片段分别与由N-芳基甘氨酸乙酯原位生成的同一中间体反应,同时生成两种产物。该反应具有效率高,操作简单和原子经济性高的优点。

更新日期:2020-08-12
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