Alzheimer's disease (AD) is a chronic neurodegenerative disease. Better imaging and early diagnosis of biomarkers of AD is extremely important for therapeutic interventions. The amyloid cascade hypothesis and its revised version identify insoluble β-amyloid deposition as a good diagnostic biomarker for AD. Moreover, lipid droplets may also act as an auxiliary biomarker related to AD pathology based on recent studies. Herein, two quinoline-based AIE probes were designed and synthesized for the imaging of Aβ plaques and lipid droplets. The probes exhibited remarkable turn-on fluorescence enhancements with the Aβ aggregates. The lipid droplets-targeting probe FB exhibited high selectivity and binding affinity towards the Aβ aggregates with a detection limit as low as 26.9 nM. Furthermore, FB was capable of readily imaging Aβ plaques and lipid droplets at the cellular level and in brain sections of transgenic AD mice. The probe FB can serve as a promising tool for developing early diagnosis and innovative therapeutics of AD.

中文翻译：

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用于成像 β-淀粉样斑块和脂滴的双功能 AIE 荧光探针

阿尔茨海默病 (AD) 是一种慢性神经退行性疾病。更好的 AD 生物标志物成像和早期诊断对于治疗干预极为重要。淀粉样蛋白级联假说及其修订版将不溶性 β-淀粉样蛋白沉积确定为 AD 的良好诊断生物标志物。此外，根据最近的研究，脂滴还可以作为与 AD 病理相关的辅助生物标志物。在此，设计并合成了两种基于喹啉的 AIE 探针，用于 Aβ 斑块和脂滴的成像。探针与 Aβ 聚集体显示出显着的开启荧光增强。脂滴靶向探针 FB 对 Aβ 聚集体表现出高选择性和结合亲和力，检测限低至 26.9 nM。此外，FB 能够在细胞水平和转基因 AD 小鼠的脑切片中轻松成像 Aβ 斑块和脂滴。探针 FB 可以作为开发 AD 早期诊断和创新疗法的有前途的工具。