Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution,Journal of Applied Polymer Science

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Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-08-10 , DOI: 10.1002/app.49779
Jia Wang ₁ , Haixin Zhang ₁ , Jie Xu ₁ , Hao Qian ₁ , Rui Liu ₁ , Zengchang Xu ₂ , Hongjun Zhu ₁

Affiliation

Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustained‐release ability in vitro , which could be used as a potential delivery system for anti‐inflammatory agents.

中文翻译：

布洛芬前药缓释颗粒：乳化剂和引发剂调节直径和分布

聚合物在药物输送系统（DDS）的开发中起着至关重要的作用。对于DDS，具有可控制的直径和分布有利于药物释放行为和功效的再现性。在这项工作中，布洛芬前药（Ibu @ PMMA）由甲基丙烯酸甲酯（MMA），布洛芬单体（Ibu @ HEMA）和乙二醇二甲基丙烯酸酯（EGDMA）通过乳液聚合合成。Ibu @ PMMA呈球形，其结构性质通过NMR，FTIR和SEM技术表征。另外，通过增加乳化剂的比例来降低Ibu @ PMMA的流体力学直径和多分散指数（PDI）。同时，通过增加引发剂的量，降低了Ibu @ PMMA的流体力学直径和PDI。此外，Ibu @ PMMA具有良好的持续释放能力在体外，这可作为潜在的递送系统为抗炎剂。

更新日期：2020-08-11

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