当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Molecular Engineering of NIR-II Fluorophores for Improved Biomedical Detection
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-08-11 , DOI: 10.1002/anie.202007040
Zuhai Lei 1, 2 , Fan Zhang 1
Affiliation  

The development of fluorophores for the second near-infrared window (NIR-II, 1000–1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, and biomedical engineering. The wavelength, brightness, and stability are three crucial factors that determine the performance of an NIR-II fluorophore. Up to now, significant progress has been made in the development of NIR-II fluorescence molecular probes, including the synthesis of D-A-D and D-π-A fluorophores with improved NIR-II fluorescence imaging performance and the construction of off–on probes and ratiometric probes via energy transfer or molecular structure modification. In this review, we summarize the most recent advances in molecular engineering design strategies of NIR-II fluorophores and probes, then highlight a selection of bioimaging and biosensing applications. We also provide perspectives on potential challenges and opportunities in this emerging field

中文翻译:

用于改进生物医学检测的 NIR-II 荧光团的分子工程

第二个近红外窗口(NIR-II,1000-1700 nm)荧光团的开发代表了分析化学、化学生物学和生物医学工程中一个新兴的、重要的和充满活力的领域。波长、亮度和稳定性是决定 NIR-II 荧光团性能的三个关键因素。迄今为止,NIR-II荧光分子探针的开发取得了重大进展,包括合成具有改进NIR-II荧光成像性能的DAD和D-π-A荧光团以及构建off-on探针和比率计。探针通过能量转移或分子结构修饰。在这篇综述中,我们总结了 NIR-II 荧光团和探针的分子工程设计策略的最新进展,然后重点介绍一系列生物成像和生物传感应用。我们还提供有关这一新兴领域潜在挑战和机遇的观点
更新日期:2020-08-11
down
wechat
bug