Polyetheretherketone (PEEK) is being used in various biomedical devices thanks to its bio-inertness, nontoxicity, and an elastic modulus near to that of human cortical bone. However, its oral and maxillofacial applications remain challenging owing to is hydrophobicity, lack of biocompatibility, and infectious complications. To address this problem, a biocompatible nanogranular-structured TiO₂ coating assisted by a mediating layer of pre-grafted polydopamine (PDA) was deposited onto PEEK to modify its surface. The PDA-mediated TiO₂ coated PEEK showed a unique surface layer of single anatase phase. The surface tended to become more hydrophilic with increased TiO₂ deposition, and even turned super-hydrophilic with a sufficient amount of deposited TiO₂. In vitro cell culture tests verified that such prepared PEEK improved adhesion and proliferation of both fibroblast and osteoblast cells, decreased the inflammatory reaction by suppressing TNF-α expression for macrophages, as well as enhanced the antibacterial activity against Staphylococcus aureus and Streptococcus mutans bacteria attachment when compared to only PDA coated and uncoated PEEK. Such a superior bio-performance is apparently correlated with anatase TiO₂, as well as its improved physiochemical surface states, including altered surface energy. The PDA-mediated TiO₂ nanostructured coating may bode well for oral and maxillofacial implants applications of PEEK.

聚醚醚酮（PEEK）具有生物惰性，无毒以及接近人类皮质骨的弹性模量，因此已被用于各种生物医学设备中。然而，由于疏水性，缺乏生物相容性和感染性并发症，其口腔和颌面部应用仍然具有挑战性。为了解决这个问题，将具有生物相容性的纳米颗粒结构的TiO ₂涂层辅以预接枝的聚多巴胺（PDA）介导层沉积在PEEK上以修饰其表面。PDA介导的TiO ₂涂层的PEEK表现出独特的单锐钛矿相表面层。随着TiO ₂沉积的增加，表面趋于变得更加亲水，甚至在沉积足够量的TiO的情况下，表面甚至变得超亲水₂。体外细胞培养试验证实，这种制备的PEEK可通过抑制巨噬细胞的TNF-α表达来改善成纤维细胞和成骨细胞的粘附和增殖，减少炎症反应，并增强对金黄色葡萄球菌和变形链球菌细菌附着的抗菌活性。与仅PDA涂层和未涂层​​PEEK相比。如此出色的生物性能显然与锐钛矿TiO ₂及其改善的物理化学表面状态（包括改变的表面能）相关。PDA介导的TiO ₂纳米结构涂层对于PEEK的口腔和颌面植入物应用可能预示着良好的前景。