Engineered Biosynthesis of Fungal 4-Quinolone Natural Products.,Organic Letters

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Engineered Biosynthesis of Fungal 4-Quinolone Natural Products.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-10 , DOI: 10.1021/acs.orglett.0c02426
Mengting Liu _{1,

2} , Masao Ohashi ₁ , Yi Tang ₁

Affiliation

Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here we uncovered a concise nonribosomal peptide synthetase pathway involved in quinolactacin A biosynthesis from Penicillium by using heterologous reconstitution and in vitro enzymatic synthesis. The N-desmethyl analog of quinolactacin A was accessed through the construction of a hybrid bacterial and fungi pathway in the heterologous host.

中文翻译：

真菌 4-喹诺酮天然产物的工程生物合成。

含喹诺酮的天然产物广泛存在于细菌、真菌和植物中。N-甲基-4-喹诺酮类真菌喹内酯类显示出广泛的生物活性。在这里，我们通过使用异源重组和体外酶促合成发现了一条简明的非核糖体肽合成酶途径，该途径参与了青霉菌的喹乳酸菌素 A 生物合成。通过在异源宿主中构建混合细菌和真菌途径，获得喹乳酸菌素 A的N-去甲基类似物。

更新日期：2020-08-21

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