Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications,Journal of the American Chemical Society

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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-08-07 , DOI: 10.1021/jacs.0c07022
Chunyan Li ₁ , Guangcun Chen ₁ , Yejun Zhang ₁ , Feng Wu ₁ , Qiangbin Wang _{1,

2}

Affiliation

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital imaging capacity in the conventional wavelength range (400-950 nm) has been restricted by the extremely limited tissue penetration. To tackle this challenge, a novel imaging approach using the fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm) has been developed in the last decade to achieve deep penetration and high-fidelity imaging, and thus significant biomedical applications have begun to emerge. In this Perspective, we first examine recent discoveries and challenges in the development of novel NIR-II fluorophores and compatible imaging apparatuses. Subsequently, the recent advances in bioimaging, biosensing, and therapy using such a cutting-edge imaging technique are highlighted. Finally, based on the achievement in the representative studies, we eluci-date the main concerns regarding this imaging technique and give some advice and prospects for the development of NIR-II imag-ing for future biomedical applications.

中文翻译：

用于生物医学应用的近红外 II 窗口中的高级荧光成像技术

荧光成像已成为生物医学应用的基本工具；然而，其在常规波长范围（400-950 nm）内的活体成像能力受到极其有限的组织穿透能力的限制。为了应对这一挑战，在过去十年中开发了一种使用第二个近红外窗口（NIR-II，1000-1700 nm）中的荧光的新型成像方法，以实现深度穿透和高保真成像，因此具有重要的生物医学意义。应用程序已经开始出现。在这个视角中，我们首先研究了在开发新型 NIR-II 荧光团和兼容成像设备方面的最新发现和挑战。随后，重点介绍了使用这种尖端成像技术的生物成像、生物传感和治疗方面的最新进展。最后，

更新日期：2020-08-07

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