用于肿瘤学的下一代高分子纳米药物：前景和未来方向。,Macromolecular Rapid Communications

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用于肿瘤学的下一代高分子纳米药物：前景和未来方向。
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-08-07 , DOI: 10.1002/marc.202000319
Nicholas L Fletcher ₁ , Kristian Kempe _{2,

3} , Kristofer J Thurecht ₁

Affiliation

精密聚合物作为先进的纳米药物代表了一种治疗无法治愈的恶性肿瘤的诱人方法。通过利用独特的纳米材料特性并执行明智的设计策略，可以生产出克服许多阻碍有效治疗的障碍的聚合物纳米药物。预计当前将在纳米药物用于肿瘤学的聚合物应用中产生最大影响的主要研究重点领域包括实现“主动”靶向，聚合物前药激活和组合聚合物药物递送方法的新策略，并加深对复杂生物纳米的理解互动。这些方法，无论是隔离还是组合，都可以构成下一代具有重大预期未来健康成果的精密纳米药物。必然这些方法将结合对生物相互作用的深入了解和先进的材料设计。本观点文章旨在突出新兴机遇，有望成为纳米医学肿瘤学领域的颠覆者。本文讨论的是当前和下一代的聚合纳米药物，其重点是已经或可能会进行临床翻译的结构，并突出了该领域的关键进展。

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Next-Generation Polymeric Nanomedicines for Oncology: Perspectives and Future Directions.

Precision polymers as advanced nanomedicines represent an appealing approach for the treatment of otherwise untreatable malignancies. By taking advantage of unique nanomaterial properties and implementing judicious design strategies, polymeric nanomedicines are able to be produced that overcome many barriers to effective treatment. Current key research focus areas anticipated to produce the greatest impact in polymer applications in nanomedicine for oncology include new strategies to achieve “active” targeting, polymeric pro‐drug activation, and combinatorial polymer drug delivery approaches in combination with enhanced understanding of complex bio‐nano interactions. These approaches, both in isolation or combination, form the next generation of precision nanomedicines with significant anticipated future health outcomes. Of necessity, these approaches will combine an intimate understanding of biological interactions with advanced materials design. This perspectives piece aims to highlight emerging opportunities that promise to be game changers in the nanomedicine oncology field. Discussed herein are current and next generation polymeric nanomedicines with a focus towards structures that are, or could, undergo clinical translation as well as highlight key advances in the field.

更新日期：2020-09-22

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