A series of 1,2-dihydronaphtho[2,1-b]furan derivatives were synthesized by cyclizing 1-(aryl/alkyl(arylthio)methyl)-naphthalen-2-ol and pyridinium bromides in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in very good yield. The synthesized compounds were evaluated for their anti-proliferative potential against human triple negative MDA-MB-468 and MCF-7 breast cancer cells and non-cancerous WI-38 cells (lung fibroblast cell) using MTT experiments. Among 21 synthesized compounds, three compounds (3a, 3b and 3 s) showed promising anti-cancer potential and compound 3b was found to have best anti-proliferative activities based on the results of several biochemical and microscopic experiments.

在1,8-二氮杂双环存在下，通过环化1-（芳基/烷基（芳硫基）甲基）-萘-2-醇和溴化吡啶鎓，合成了一系列1,2-二氢萘并[2,1- b ]呋喃衍生物[5.4.0]十一碳7烯（DBU）的收率非常好。使用MTT实验评估了合成的化合物对人三阴性MDA-MB-468和MCF-7乳腺癌细胞以及非癌性WI-38细胞（肺成纤维细胞）的抗增殖潜力。在21种合成化合物中，三种化合物（3a，3b和3 s）显示出有希望的抗癌潜力，并且根据一些生化和微观实验的结果，发现化合物3b具有最佳的抗增殖活性。