Organocatalytic Atroposelective Construction of Axially Chiral N-Aryl Benzimidazoles Involving Carbon-Carbon Bond Cleavage.,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Organocatalytic Atroposelective Construction of Axially Chiral N-Aryl Benzimidazoles Involving Carbon-Carbon Bond Cleavage.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-05 , DOI: 10.1021/acs.orglett.0c02214
Ningning Man ₁ , Zhenbang Lou ₁ , Yuming Li ₁ , Haijun Yang ₁ , Yufen Zhao ₁ , Hua Fu ₁

Affiliation

Axially chiral compounds widely occur in natural products, biologically active molecules, ligands, and catalysts, and their efficient and enantioselective synthesis is highly desirable. Herein, we report a novel method for the atroposelective construction of axially chiral N-aryl benzimidazoles with chiral phosphoric acid as the organocatalyst via reaction of N¹-(aryl)benzene-1,2-diamines with multicarbonyl compounds. The present method provided the target products in high yields (up to 89%) with excellent enantioselectivity (up to 98% ee).

中文翻译：

涉及碳-碳键断裂的轴向手性N-芳基苯并咪唑的有机催化对映选择性构建。

轴向手性化合物广泛存在于天然产物，生物活性分子，配体和催化剂中，非常需要它们的有效和对映选择性合成。在这里，我们报告了一种新型的轴向手性N-芳基苯并咪唑与手性磷酸作为有机催化剂通过N ^1-（芳基苯-1,2-二胺与多羰基化合物反应）的对映选择性构建的新方法。本方法以高收率（高达89％）提供了优异的对映选择性（高达98％ee）的目标产物。

更新日期：2020-08-21

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南