Kahweol Reduces Food Intake of Caenorhabditis elegans.,Journal of Agricultural and Food Chemistry

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Kahweol Reduces Food Intake of Caenorhabditis elegans.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-08-06 , DOI: 10.1021/acs.jafc.0c03030
Renalison Farias-Pereira ₁ , Cheon-Seok Park ₂ , Yeonhwa Park _{1,

2}

Affiliation

The coffee diterpene kahweol may contribute to the anti-obesity effects of coffee but its physiological effects have yet to be elucidated. Caenorhabditis elegans is used as an animal model in obesity research because its lipid metabolism is conserved in humans. The goal was to investigate kahweol’s effects on lipid metabolism in C. elegans. Kahweol at 120 μM reduced fat accumulation by 17% compared to the control, which was associated with a reduced food intake. Kahweol did not reduce fat in eat-2 mutants, which have a disrupted pharynx contraction rate, suggesting that the fat-lowering effects of kahweol were dependent on food intake. Lipid metabolism-related gene homologues of tubby protein (tub-1), enoyl-CoA hydratase (ech-1.1), adipose triglyceride lipase (atgl-1), insulin/insulin-like growth receptor (daf-2), and forkhead box O transcription factor (daf-16) were also associated with changes in food intake by kahweol. Therefore, kahweol’s fat-lowering effects are due to a reduction of food intake in C. elegans.

中文翻译：

Kahweol减少秀丽隐杆线虫的食物摄入。

咖啡二萜烯甘露醇可能有助于咖啡的抗肥胖作用，但尚未阐明其生理作用。秀丽隐杆线虫被用作肥胖症研究中的动物模型，因为其脂质代谢在人类中是保守的。目的是研究卡赫威尔对秀丽隐杆线虫脂质代谢的影响。与对照组相比，120μM的Kahweol减少了17％的脂肪积累，这与食物摄入减少有关。Kahweol并未减少eat-2突变体中的脂肪，后者突变了咽部的收缩速率，这表明kahweol的降脂作用取决于食物的摄入量。图比蛋白（tub-1），烯酰辅酶A水合酶（）的脂质代谢相关基因同源物ech-1.1），脂肪甘油三酸酯脂肪酶（atgl-1），胰岛素/胰岛素样生长受体（daf-2）和叉头盒O转录因子（daf-16）也与卡赫韦尔的食物摄入量变化有关。因此，kahweol的降脂作用是由于秀丽隐杆线虫的食物摄入减少。

更新日期：2020-09-10

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