Transition-Metal-Catalyzed Denitrative Coupling of Nitroarenes,ACS Catalysis

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Transition-Metal-Catalyzed Denitrative Coupling of Nitroarenes
ACS Catalysis ( IF 11.3 ) Pub Date : 2020-08-06 , DOI: 10.1021/acscatal.0c02990
Kei Muto ₁ , Toshimasa Okita ₂ , Junichiro Yamaguchi ₂

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Functionalization of arenes is a topic of central importance in diverse fields ranging from medicinal chemistry to materials science. Metal-catalyzed cross-coupling and nucleophilic aromatic substitution are among the most reliable methods to access functionalized arenes. In these reactions, haloarenes are often used as a versatile synthetic platform to introduce various functional groups. However, haloarenes are typically prepared from the corresponding nitroarenes through the classic sequence of reduction, diazotization, and halogenation. Thus, haloarene cross-coupling can become a multistep transformation overall. To avoid this lengthy sequence, the direct utilization of nitroarenes has the potential to significantly streamline synthetic processes and, therefore, has attracted attention in the chemistry community from the vantage points of atom- and step-economy. In this Review, we comprehensively cover advances in transition-metal-catalyzed denitrative reactions of nitroarenes.

中文翻译：

过渡金属催化硝基芳烃的反硝化偶联

芳烃的功能化是从药物化学到材料科学的各个领域中至关重要的主题。金属催化的交叉偶联和亲核芳族取代是访问官能化芳烃的最可靠方法之一。在这些反应中，卤代芳烃通常用作引入各种官能团的通用合成平台。然而，卤代芳烃通常通过还原，重氮化和卤化的经典顺序由相应的硝基芳烃制备。因此，卤代芳烃交叉偶联可以整体上成为多步转化。为避免这一冗长的过程，直接利用硝基芳烃有可能大大简化合成过程，因此，从原子经济学和阶梯经济学的角度出发，化学界已经引起了人们的关注。在本综述中，我们全面介绍了硝基芳烃在过渡金属催化的反硝化反应中的进展。

更新日期：2020-09-05

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