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Recent advances in supramolecular block copolymers for biomedical applications.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-08-04 , DOI: 10.1039/d0tb01492c
Wumaier Yasen 1 , Ruijiao Dong 2 , Aliya Aini 3 , Xinyuan Zhu 4
Affiliation  

Supramolecular block copolymers (SBCs) have received considerable interest in polymer chemistry, materials science, biomedical engineering and nanotechnology owing to their unique structural and functional advantages, such as low cytotoxicity, outstanding biodegradability, smart environmental responsiveness, and so forth. SBCs comprise two or more different homopolymer subunits linked by noncovalent bonds, and these polymers, in particular, combine the dynamically reversible nature of supramolecular polymers with the hierarchical microphase-separated structures of block polymers. A rapidly increasing number of publications on the synthesis and applications of SBCs have been reported in recent years; however, a systematic summary of the design, synthesis, properties and applications of SBCs has not been published. To this end, this review provides a brief overview of the recent advances in SBCs and describes the synthesis strategies, properties and functions, and their widespread applications in drug delivery, gene delivery, protein delivery, bioimaging and so on. In this review, we aim to elucidate the general concepts and structure–property relationships of SBCs, as well as their practical bioapplications, shedding further valuable insights into this emerging research field.

中文翻译:

用于生物医学的超分子嵌段共聚物的最新进展。

超分子嵌段共聚物(SBC)由于其独特的结构和功能优势(例如低细胞毒性,出色的生物降解性,灵敏的环境响应性等)而在聚合物化学,材料科学,生物医学工程和纳米技术领域引起了极大的兴趣。SBC包含通过非共价键连接的两个或多个不同的均聚物亚基,这些聚合物尤其将超分子聚合物的动态可逆性质与嵌段聚合物的分级微相分离结构结合在一起。近年来,有关SBC的合成和应用的出版物迅速增加。但是,尚未发表有关单板电脑的设计,合成,性质和应用的系统摘要。为此,这篇综述简要概述了SBC的最新进展,并描述了合成策略,性质和功能及其在药物递送,基因递送,蛋白质递送,生物成像等方面的广泛应用。在这篇综述中,我们旨在阐明SBC的一般概念,结构与属性之间的关系,以及它们的实际生物应用,为这一新兴的研究领域提供更多有价值的见解。
更新日期:2020-09-23
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