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Commensal Relationship of Three Bifidobacterial Species Leads to Increase of Bifidobacterium in Vitro Fermentation of Sialylated Immunoglobulin G by Human Gut Microbiota.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-08-04 , DOI: 10.1021/acs.jafc.0c03628 Chunxu Chen 1, 2 , Tianhui Li 1 , Guijie Chen 1 , Dan Chen 1 , Yujia Peng 1 , Bing Hu 1 , Yi Sun 1 , Xiaoxiong Zeng 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-08-04 , DOI: 10.1021/acs.jafc.0c03628 Chunxu Chen 1, 2 , Tianhui Li 1 , Guijie Chen 1 , Dan Chen 1 , Yujia Peng 1 , Bing Hu 1 , Yi Sun 1 , Xiaoxiong Zeng 1
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Sialylated immunoglobulin G (IgG) is an important immunoglobulin in breast milk, but its effect on adult gut microbiota is not yet clear due to digestion by pepsin. Based on our previous IgG protecting study, effects of sialylated IgG on gut microbiota were investigated by in vitro anaerobic fermentation in the present study. It was found that the addition of sialylated IgG could significantly promote the growth of Bifidobacterium. Meanwhile, three bifidobacterial species B. bifidum CCX 19061, Bembidion breve CCX 19041, and B. longum subsp. infantis CCX 19042 were isolated. Furthermore, B. breve CCX 19041 and B. longum subsp. infantis CCX 19042 showed co-culture growth property with B. bifidum CCX 19061 in a sialylated IgG-based medium, which was also supported by changes of free monosaccharides and N-glycan structure. These findings suggest that the increase of Bifidobacterium in vitro fermentation is attributed to the commensal relationship of the three bifidobacterial species by utilizing sugars released from sialylated IgG.
中文翻译：
三种双歧杆菌物种的共生关系导致人肠道菌群对唾液酸化免疫球蛋白G的体外发酵导致双歧杆菌增加。
唾液酸化的免疫球蛋白G（IgG）是母乳中的重要免疫球蛋白，但是由于胃蛋白酶的消化作用，其对成年肠道微生物群的影响尚不清楚。基于我们先前的IgG保护研究，本研究通过体外厌氧发酵研究了唾液酸化IgG对肠道菌群的影响。发现唾液酸化IgG的加入可以明显促进双歧杆菌的生长。同时，三个双歧杆菌种B. bifidum CCX 19061，Bembidion breve CCX 19041和B. longum亚种。隔离婴儿CCX 19042。此外，短双歧杆菌CCX 19041和长双歧杆菌B.subum。婴儿CCX 19042与双歧杆菌CCX 19061在唾液酸化的基于IgG的培养基中共培养具有生长特性，这也受到游离单糖和N-聚糖结构变化的支持。这些发现表明，通过利用从唾液酸化的IgG释放的糖，双歧杆菌体外发酵的增加归因于三种双歧杆菌物种的共生关系。
更新日期：2020-08-26
中文翻译：
三种双歧杆菌物种的共生关系导致人肠道菌群对唾液酸化免疫球蛋白G的体外发酵导致双歧杆菌增加。
唾液酸化的免疫球蛋白G（IgG）是母乳中的重要免疫球蛋白，但是由于胃蛋白酶的消化作用，其对成年肠道微生物群的影响尚不清楚。基于我们先前的IgG保护研究，本研究通过体外厌氧发酵研究了唾液酸化IgG对肠道菌群的影响。发现唾液酸化IgG的加入可以明显促进双歧杆菌的生长。同时，三个双歧杆菌种B. bifidum CCX 19061，Bembidion breve CCX 19041和B. longum亚种。隔离婴儿CCX 19042。此外，短双歧杆菌CCX 19041和长双歧杆菌B.subum。婴儿CCX 19042与双歧杆菌CCX 19061在唾液酸化的基于IgG的培养基中共培养具有生长特性，这也受到游离单糖和N-聚糖结构变化的支持。这些发现表明，通过利用从唾液酸化的IgG释放的糖，双歧杆菌体外发酵的增加归因于三种双歧杆菌物种的共生关系。
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