Construction of Axially Chiral Compounds via Central-to-Axial Chirality Conversion.,Chemistry - An Asian Journal

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Construction of Axially Chiral Compounds via Central-to-Axial Chirality Conversion.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-08-05 , DOI: 10.1002/asia.202000681
Hui Yang ₁ , Jie Chen ₁ , Ling Zhou ₁

Affiliation

Central‐to‐axial chirality conversion represents a fascinating class of chemical processes consisting of the destruction of stereogenic centers and the simultaneous installation of axial chiral elements, which provides efficient methods for the preparation of axially chiral compounds. Using the strategy, a wide range of axially chiral compounds, including biaryls, heterobiaryls, aromatic amides, allenes and vinyl arenes, have been synthesized with high efficiency and excellent enantioselectivity. In addition, central‐to‐axial chirality conversion strategy has been applied to the synthesis of natural products. The strategy has undoubtedly become and will continue to be a hot research topic in the field of asymmetric catalysis and synthesis. In this minireview, we selected some examples to introduce the developments and trends in the central‐to‐axial chirality conversion strategy up to April 2020.

中文翻译：

通过中心-轴向手性转化构建轴向手性化合物。

中心到轴向手性的转化代表了令人着迷的一类化学过程，包括立体异构中心的破坏和轴向手性元素的同时安装，这为制备轴向手性化合物提供了有效的方法。使用该策略，已经以高效率和优异的对映选择性合成了多种轴向手性化合物，包括联芳基，杂联二芳基，芳族酰胺，丙二烯和乙烯基芳烃。此外，从中心到手性的手性转换策略已应用于天然产物的合成。该策略无疑已经成为并且将继续成为不对称催化和合成领域的热门研究课题。在这份迷你评论中，

更新日期：2020-10-02

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