The synthetic fragrance 2-(4-tert-butylbenzyl)propionaldehyde, also known as lysmeral, butylphenyl methylpropional, lilial, or lily aldehyde, is widely used in cosmetics, personal care products, laundry detergents, and air fresheners. It is classified as suspected to be harmful to fertility and possibly endocrine disrupting. Its maximum concentration in cosmetics is limited.

First-morning void urine samples (N = 2133) were analysed for several metabolites of lysmeral (Chemical Abstract Service (CAS) No.: 80-54-6). Samples were collected in the population-representative German Environmental Survey for Children and Adolescents 2014–2017 (GerES V) from German residents aged 3–17 years. Four main metabolites tert-butylbenzoic acid, lysmerol, lysmerylic acid, and hydroxy-lysmerylic acid were found in quantifiable amounts in 100%, 99%, 40%, and 23% of the samples, respectively, with geometric mean concentrations of 10.21 μg/L (8.658 μg/g_crea) for tert-butylbenzoic acid, 1.528 μg/L (1.296 μg/g_crea) for lysmerol, and below the limit of quantification of 0.2 μg/L and 0.4 μg/L for lysmerylic acid and hydroxy-lysmerylic acid, respectively.

Girls had higher urinary concentrations of lysmeral metabolites than boys. Usage of fragrances, fabric softener, and personal care products, especially perfume, was positively associated with urinary concentrations of lysmeral metabolites. Source identification builds a basis to derive proposals for reduction of exposure.

These results can also provide the foundation for developing reference values for urinary metabolite concentrations of lysmeral in children and adolescents in Germany that will facilitate recognising future exposure trends.

合成香料2-（4-叔丁基苄基）丙醛，也称为赖氨醛，丁基苯基甲基丙醛，百合醛或百合醛，广泛用于化妆品，个人护理产品，洗衣粉和空气清新剂中。它被分类为被怀疑对生育有害，并可能破坏内分泌。其在化妆品中的最大浓度是有限的。

分析了第一时间清晨尿液样本（N = 2133）中赖氨酸的几种代谢物（化学文摘社（CAS）编号：80-54-6）。在2014-2017年德国代表性儿童和青少年环境调查（GerES V）中，样本收集了3-17岁的德国居民。分别以100％，99％，40％和23％的样品定量定量发现了四种主要代谢物叔丁基苯甲酸，麦草酚，麦草酸和羟基麦草酸，几何平均浓度为10.21μg/ L（8.658微克/克_CREA）为叔-butylbenzoic酸，1.528微克/升（1.296微克/克_CREA）的含量为lysmerolol，低于200μg/ L和0.4μg/ L的定量值。

女孩的尿液赖氨酸代谢产物浓度高于男孩。香水，织物柔软剂和个人护理产品（尤其是香水）的使用与尿液中的赖氨酸代谢产物呈正相关。来源识别为得出减少接触的建议奠定了基础。

这些结果也可以为开发德国儿童和青少年赖氨酸的尿代谢物浓度参考值提供基础，这将有助于识别未来的暴露趋势。