Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.,Acta Crystallographica Section F

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Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.
Acta Crystallographica Section F ( IF 1.1 ) Pub Date : 2020-08-03 , DOI: 10.1107/s2053230x20009012
Shunya Sakurai ₁ , Toshiyuki Shimizu ₁ , Umeharu Ohto ₁

Affiliation

FYCO1 is a multidomain adaptor protein that plays an important role in autophagy by mediating the kinesin‐dependent microtubule plus‐end‐directed transport of autophagosomes. FYCO1 contains a RUN domain, which is hypothesized to function as a specific effector for members of the Ras superfamily of small GTPases, but its role has not been well characterized and its interaction partner(s) have not been identified. Here, the crystal structure of the FYCO1 RUN domain was determined at 1.3 Å resolution. The overall structure of the FYCO1 RUN domain was similar to those of previously reported RUN domains. Detailed structural comparisons with other RUN domains and docking studies suggested a possible interaction interface of the FYCO1 RUN domain with small GTPases of the Ras superfamily.

中文翻译：

FYCO1 RUN 结构域的晶体结构表明可能与小 GTPases 存在接口。

FYCO1 是一种多域衔接蛋白，通过介导自噬体的驱动蛋白依赖性微管加末端定向运输，在自噬中发挥重要作用。FYCO1 包含一个 RUN 结构域，假设它作为小 GTP 酶 Ras 超家族成员的特异性效应子，但其作用尚未得到很好的表征，其相互作用伙伴也尚未确定。此处，FYCO1 RUN 结构域的晶体结构以 1.3 Å 分辨率测定。FYCO1 RUN 结构域的整体结构与之前报道的 RUN 结构域相似。与其他 RUN 结构域的详细结构比较和对接研究表明 FYCO1 RUN 结构域与 Ras 超家族的小 GTP 酶可能存在相互作用界面。

更新日期：2020-08-03

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