Individual negative symptoms have rarely been examined with regard to their relationship with suicide in schizophrenia, which continues to affect up to 13% of people with the disorder. Symptoms such as blunted affect, which can be an enduring hallmark of schizophrenia, may impact suicide through increasing isolation, leading to poor functional recovery and diminished quality of life. A systematic review following PRISMA guidelines and pre-registered on PROSPERO (CRD4219143373) was conducted; EMBASE, PsychInfo, and MedLine were searched until January 2020. Eight hundred and fifty-six articles were identified from the databases and 2 papers were identified from other resources. Twelve papers met inclusion criteria for the review. Nine out of twelve papers report a positive direct or indirect association between blunted affect and suicide in schizophrenia and three papers showed no association. The majority of included studies suggest that blunted affect may be indirectly related to suicide through risk factors such as emotional withdrawal, depressive symptoms, hopelessness, low self-esteem and negative evaluation. Future studies should include assessment of blunted affect as a potential mediator in the generation of suicidal behaviour in patients with such factors.

很少有人对精神分裂症中与自杀的关系进行过个体阴性症状的检查，该现象继续影响多达13％的精神分裂症患者。诸如钝痛之类的症状可能是精神分裂症的持久特征，它可能通过增加隔离度来影响自杀，导致功能恢复不良和生活质量下降。根据PRISMA指南并在PROSPERO（CRD4219143373）上预先注册了系统的审查；一直搜索到EMBASE，PsychInfo和MedLine，直到2020年1月。从数据库中识别出856篇文章，从其他资源中识别出2篇论文。十二篇论文符合纳入标准。12篇论文中有9篇报道精神分裂症的钝性情感与自杀之间存在直接或间接的正相关，而3篇论文则没有相关性。大多数纳入研究表明，钝化的影响可能通过情绪低落，抑郁症状，绝望，自卑和负面评价等风险因素与自杀间接相关。未来的研究应包括评估钝性影响作为具有此类因素的患者自杀行为产生的潜在媒介。