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Formation of Sulfobetaine-Containing Entirely Ionic PIC (Polyion Complex) Micelles and Their Temperature Responsivity.
Langmuir ( IF 3.7 ) Pub Date : 2020-08-02 , DOI: 10.1021/acs.langmuir.0c01577 Dongwook Kim 1 , Hideki Matsuoka 1 , Yoshiyuki Saruwatari 2
Langmuir ( IF 3.7 ) Pub Date : 2020-08-02 , DOI: 10.1021/acs.langmuir.0c01577 Dongwook Kim 1 , Hideki Matsuoka 1 , Yoshiyuki Saruwatari 2
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Sulfobetaine, a type of zwitterionic polymer, is highly biocompatible with temperature responsiveness of the upper critical solution temperature (UCST) type. The objective of this research was to construct polyion complex (PIC) micelles in the shell of sulfobetaine that had these properties. We used poly(sulfopropyl dimethylammonium propylacrylamide) (PSPP) as sulfobetaine, poly(sodium styrenesulfonate) (PSSNa) as the anionic polymer, and poly[3-(methacrylamido)propyl trimethylammonium chloride] (PMAPTAC) as the cationic polymer. The fundamental properties of the sulfobetaine-containing polymer and the complex were investigated to construct micelles in which the corona expands and contracts in response to temperature changes. Changes in the cloud point were observed from the transmittance for sulfobetaine homopolymers with different degrees of polymerization and concentration and aqueous solution of temperature-responsive diblock copolymers with different concentrations. The concentration and degree of polymerization dependencies on temperature responsivity were determined. Then we mixed two diblock copolymer aqueous solutions that did not have temperature responsivity so that the charge number of anions and cations became equal, and the temperature responsivity and the formation of micelles were confirmed from 1H NMR, DLS, and transmittance. This confirmed the formation of PIC micelles with temperature responsivity. The diblock copolymer did not have temperature responsivity due to the influence of the block ratio by introduction of the ionic chain. However, it is considered to have temperature responsivity because the ionic chain becomes the core when PIC micelles are formed. Furthermore, the PIC micelles with temperature responsivity also had a degree of polymerization and concentration dependencies.
中文翻译：
含磺基甜菜碱的完全离子型PIC（聚阴离子络合物）胶束的形成及其温度响应性。
磺基甜菜碱是两性离子聚合物的一种，与上临界溶液温度（UCST）类型的温度响应能力高度生物相容。这项研究的目的是在磺基甜菜碱的外壳中构建具有这些特性的聚离子复合物（PIC）胶束。我们使用聚（磺丙基丙基二甲基铵丙基丙烯酰胺）（PSPP）作为磺基甜菜碱，聚（苯乙烯磺酸钠）（PSSNa）作为阴离子聚合物，以及聚[3-（甲基丙烯酰胺基）丙基三甲基氯化铵]（PMAPTAC）作为阳离子聚合物。研究了含磺基甜菜碱的聚合物和配合物的基本性质，以构建胶束，其中电晕响应温度变化而膨胀和收缩。从具有不同聚合度和浓度的磺基甜菜碱均聚物的透射率以及具有不同浓度的温度响应性二嵌段共聚物的水溶液观察到浊点的变化。确定了浓度和聚合度对温度响应性的依赖性。然后，我们将两种不具有温度响应性的二嵌段共聚物水溶液混合，以使阴离子和阳离子的电荷数相等，并从中确认了温度响应性和胶束的形成。1 H NMR，DLS和透射率。这证实了具有温度响应性的PIC胶束的形成。由于引入离子链对嵌段比率的影响，二嵌段共聚物不具有温度响应性。然而，由于当形成PIC胶束时离子链成为核心，因此认为它具有温度响应性。此外，具有温度响应性的PIC胶束还具有一定程度的聚合度和浓度依赖性。
更新日期：2020-09-01
中文翻译：
含磺基甜菜碱的完全离子型PIC（聚阴离子络合物）胶束的形成及其温度响应性。
磺基甜菜碱是两性离子聚合物的一种，与上临界溶液温度（UCST）类型的温度响应能力高度生物相容。这项研究的目的是在磺基甜菜碱的外壳中构建具有这些特性的聚离子复合物（PIC）胶束。我们使用聚（磺丙基丙基二甲基铵丙基丙烯酰胺）（PSPP）作为磺基甜菜碱，聚（苯乙烯磺酸钠）（PSSNa）作为阴离子聚合物，以及聚[3-（甲基丙烯酰胺基）丙基三甲基氯化铵]（PMAPTAC）作为阳离子聚合物。研究了含磺基甜菜碱的聚合物和配合物的基本性质，以构建胶束，其中电晕响应温度变化而膨胀和收缩。从具有不同聚合度和浓度的磺基甜菜碱均聚物的透射率以及具有不同浓度的温度响应性二嵌段共聚物的水溶液观察到浊点的变化。确定了浓度和聚合度对温度响应性的依赖性。然后，我们将两种不具有温度响应性的二嵌段共聚物水溶液混合，以使阴离子和阳离子的电荷数相等，并从中确认了温度响应性和胶束的形成。1 H NMR，DLS和透射率。这证实了具有温度响应性的PIC胶束的形成。由于引入离子链对嵌段比率的影响，二嵌段共聚物不具有温度响应性。然而，由于当形成PIC胶束时离子链成为核心，因此认为它具有温度响应性。此外，具有温度响应性的PIC胶束还具有一定程度的聚合度和浓度依赖性。
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