ZIF-8-Modified Multifunctional Bone-Adhesive Hydrogels Promoting Angiogenesis and Osteogenesis for Bone Regeneration.,ACS Applied Materials & Interfaces

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ZIF-8-Modified Multifunctional Bone-Adhesive Hydrogels Promoting Angiogenesis and Osteogenesis for Bone Regeneration.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-07-29 , DOI: 10.1021/acsami.0c12090
Yanhua Liu ₁ , Zhou Zhu ₁ , Xibo Pei ₁ , Xin Zhang ₁ , Xinting Cheng ₁ , Shanshan Hu ₁ , Xiaomeng Gao ₁ , Jian Wang ₁ , Junyu Chen ₁ , Qianbing Wan ₁

Affiliation

Designing bone adhesives with adhesiveness, antideformation, biocompatibility, and biofunctional effects has great practical significance for bone defect reconstructive treatment, especially for bone graft repair surgery. Here, we designed zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP)-modified catechol–chitosan (CA-CS) multifunctional hydrogels (CA-CS/Z) to stabilize the bone graft environment, ensure blood supply, promote osteogenic differentiation, and accelerate bone reconstruction. Characterizations confirmed the successful synthesis of CA-CS/Z hydrogels. Hydrogels exhibited advanced rheological properties, reliable mechanical strength, and excellent adhesion for clinical applications. Based on excellent biocompatibility, it could enhance paracrine of the vascular endothelial growth factor (VEGF) in rat bone marrow mesenchymal stem cells (rBMSCs) to ensure blood supply reconstruction in bone defect areas. Furthermore, the ZIF-8 NPs released from the hydrogels could also up-regulate the production and secretion of alkaline phosphatase, collagen 1, and osteocalcin, promoting the osteogenic differentiation of rBMSCs. In addition, the antibacterial properties of CA-CS/Z could also be observed. In vivo experiments further provided a powerful proof that CA-CS/Z promoted vascularized osteogenesis in wound areas by stabilizing bone graft materials and greatly accelerated the speed and healing of bone reconstruction. These results indicate the promising potential of CA-CS/Z hydrogels with promoting implantation stability, angiogenesis, and osteogenesis for bone regeneration applications.

中文翻译：

ZIF-8修饰的多功能骨粘合水凝胶，可促进血管再生和成骨作用，促进骨骼再生。

设计具有粘附性，抗变形性，生物相容性和生物功能作用的骨粘合剂对骨缺损的修复治疗，特别是对植骨修复手术具有重要的现实意义。在这里，我们设计了沸石咪唑盐骨架8纳米颗粒（ZIF-8 NP）改性的儿茶酚-壳聚糖（CA-CS）多功能水凝胶（CA-CS / Z），以稳定骨移植环境，确保血液供应，促进成骨分化，并加速骨骼重建。表征证实了CA-CS / Z水凝胶的成功合成。水凝胶显示出先进的流变性能，可靠的机械强度和极佳的临床应用附着力。基于出色的生物相容性，它可以增强大鼠骨髓间充质干细胞（rBMSCs）中血管内皮生长因子（VEGF）的旁分泌，以确保骨缺损区域的血液供应重建。此外，从水凝胶中释放的ZIF-8 NPs还可以上调碱性磷酸酶，胶原蛋白1和骨钙素的产生和分泌，从而促进rBMSC的成骨分化。另外，还可以观察到CA-CS / Z的抗菌特性。体内实验进一步提供了有力的证据，证明CA-CS / Z通过稳定骨移植材料促进伤口区域的血管化成骨，并大大加快了骨重建的速度和愈合速度。这些结果表明，CA-CS / Z水凝胶具有促进植入稳定性，血管生成，

更新日期：2020-08-19

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