Smart Microenvironment-Responsive Organocopper(II) Supramolecular Polymers to Regulate the Stability and Anticancer Efficacy by Different Substituents.,ACS Applied Materials & Interfaces

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Smart Microenvironment-Responsive Organocopper(II) Supramolecular Polymers to Regulate the Stability and Anticancer Efficacy by Different Substituents.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-07-28 , DOI: 10.1021/acsami.0c09919
Lanhai Lai ₁ , Zushuang Xiong ₁ , Li Ma ₁ , Tianfeng Chen ₁

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The search for chemotherapeutic drugs with a high efficiency and low toxicity continues to be a challenge in tumor treatment for scientists. Organometallic supramolecular polymers are an attractive option to achieve this goal, not only due to the fact that they possess both advantages of metal complexes and nanostructures but also because they are usually sensitive to pH. Here, we report the design and synthesis of a series novel smart microenvironment-responsive organocopper(II) supramolecular polymers with various substituted ligands to regulate their stability and anticancer efficacy. The investigation of the possible mechanisms revealed that the organocopper(II) polymers enter cancer cells through endocytosis and then induce apoptosis of cancer cells. Furthermore, the in vivo anticancer efficacy study demonstrated that these organocopper(II) polymers inhibited the tumor growth effectively without damage to the major organs. Overall, the organocopper(II) supramolecular polymers present a promising pathway to achieve high-efficiency and low-toxicity chemotherapy.

中文翻译：

智能微环境响应性有机铜（II）超分子聚合物，可调节不同取代基的稳定性和抗癌功效。

寻找高效率和低毒性的化学治疗药物仍然是科学家治疗肿瘤的挑战。有机金属超分子聚合物是实现该目标的一个有吸引力的选择，这不仅是因为它们同时具有金属配合物和纳米结构的优点，而且还因为它们通常对pH敏感。在这里，我们报告设计和合成一系列新型智能微环境响应有机铜（II）超分子聚合物与各种取代的配体，以调节其稳定性和抗癌功效。对可能机制的研究表明，有机铜（II）聚合物通过内吞作用进入癌细胞，然后诱导癌细胞凋亡。此外，体内抗癌功效研究表明，这些有机铜（II）聚合物可有效抑制肿瘤生长，而不会损害主要器官。总体而言，有机铜（II）超分子聚合物为实现高效率和低毒性的化学疗法提供了有希望的途径。

更新日期：2020-09-10

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