Abstract

The synthesis of a new library of polyheterocyclic 11H-pyrido[2,1-b]quinazolin-11-one derivatives was investigated. Satisfactory conditions were obtained via sequential C–N Buchwald–Hartwig coupling and pyridine dearomatization. In this work, traditional solvents were replaced by the bio-sourced eucalyptol, confirming the interest in it as a green solvent in chemistry.

中文翻译：

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Buchwald-Hartwig偶联/吡啶脱芳香化序列在桉油精中合成苯并融合的11H-吡啶基[2,1-b]喹唑啉-11-酮

摘要

研究了一个新的多杂环11 H-吡啶并[2,1 - b ]喹唑啉-11-one衍生物库的合成。通过连续的C–N Buchwald–Hartwig偶联和吡啶脱芳香化作用可获得令人满意的条件。在这项工作中，传统的溶剂被生物来源的桉树油所替代，证实了其在化学中作为绿色溶剂的兴趣。