An efficient synthesis of 6‐benzyl‐2‐arylthieno[2,3‐d]pyrimidin‐4(3H)‐ones catalyzed by HCl involving a Friedel‐Crafts alkylation reaction,Journal of Heterocyclic Chemistry

当前位置： X-MOL 学术 › J. Heterocycl. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

An efficient synthesis of 6‐benzyl‐2‐arylthieno[2,3‐d]pyrimidin‐4(3H)‐ones catalyzed by HCl involving a Friedel‐Crafts alkylation reaction
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-07-27 , DOI: 10.1002/jhet.4107
Wan‐Chen Pan ₁ , Yi‐Chun Wang ₁ , Tuan‐Jie Li ₁ , Jian‐Quan Liu ₁ , Xiang‐Shan Wang ₁

Affiliation

Aldehyde could undergo not only the subsequent condensation and cyclization with 2‐aminothiophene‐3‐carboxamide to build a pyrimidine ring, but also a Friedel‐Crafts alkylation reaction with thiophene moiety to give unexpected 6‐benzyl‐2‐arylthieno[2,3‐d]pyrimidin‐4(3H)‐ ones in good yields catalyzed by concentrated HCl.

中文翻译：

HCl催化的Friedel-Crafts烷基化反应有效合成6-苄基-2-芳基噻吩并[2,3-d]嘧啶-4（3H）-酮

乙醛不仅可以随后与2-氨基噻吩-3-羧酰胺进行缩合和环化以构建一个嘧啶环，而且还可以与噻吩部分进行Friedel-Crafts烷基化反应，从而产生意想不到的6-苄基-2-芳基噻吩并[2,3- d ]嘧啶-4（3 H）-浓HCl催化收率高。

更新日期：2020-07-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南