Oxidative stress is considered as one of the pathogenesis of Alzheimer’s disease (AD) and plays an important role in the occurrence and development of AD. Nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulatory of oxidative stress defence. There is growing evidence indicating the relationship between NRF2 and AD. NRF2 activation mitigates multiple pathogenic processes involved in AD by upregulating antioxidative defense, inhibiting neuroinflammation, improving mitochondrial function, maintaining proteostasis, and inhibiting ferroptosis. In addition, several NRF2 activators are currently being evaluated as AD therapeutic agents in clinical trials. Thus, targeting NRF2 has been the focus of a new strategy for prevention and treatment of AD. In this review, the role of NRF2 in AD and the NRF2 activators advanced into clinical and preclinical studies will be summarzied.

氧化应激被认为是阿尔茨海默氏病（AD）的发病机理之一，并且在AD的发生和发展中起着重要作用。核因子红系2相关因子2（NRF2）是氧化应激防御的关键调节因子。越来越多的证据表明NRF2和AD之间的关系。NRF2激活可通过上调抗氧化防御，抑制神经炎症，改善线粒体功能，维持蛋白稳定和抑制肥大症来缓解AD中涉及的多种致病过程。此外，目前正在临床试验中评估几种NRF2激活剂作为AD治疗剂。因此，靶向NRF2已经成为预防和治疗AD的新策略的焦点。在这篇评论中