当前位置: X-MOL 学术J. Mater. Chem. B › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-07-27 , DOI: 10.1039/d0tb01220c
Seungil Kim 1 , Sang-Ho Ye 1 , Arianna Adamo 2 , Ryan A Orizondo 3 , Jaehyuk Jo 4 , Sung Kwon Cho 4 , William R Wagner 5
Affiliation  

Polydimethylsiloxane (PDMS) is commonly used in medical devices because it is non-toxic and stable against oxidative stress. Relatively high blood platelet adhesion and the need for chemical crosslinking through curing, however, limit its utility. In this research, a biostable PDMS-based polyurethane-urea bearing zwitterion sulfobetaine (PDMS-SB-UU) was synthesized for potential use in the fabrication or coating of blood-contacting devices, such as a conduits, artificial lungs, and microfluidic devices. The chemical structure and physical properties of synthesized PDMS-SB-UU were confirmed by 1H-nuclear magnetic resonance (1H-NMR), X-ray diffraction (XRD), and uniaxial stress–strain curve. In vitro stability of PDMS-SB-UU was confirmed against lipase and 30% H2O2 for 8 weeks, and PDMS-SB-UU demonstrated significantly higher resistance to fibrinogen adsorption and platelet deposition compared to control PDMS. Moreover, PDMS-SB-UU showed a lack of hemolysis and cytotoxicity with whole ovine blood and rat vascular smooth muscle cells (rSMCs), respectively. The PDMS-SB-UU was successfully processed into small-diameter (0.80 ± 0.05 mm) conduits by electrospinning and coated onto PDMS- and polypropylene-based blood-contacting biomaterials due to its unique physicochemical characteristics from its soft- and hard- segments.

中文翻译:


一种基于 PDMS 的生物稳定、防污两性离子聚氨酯脲,用于血液接触医疗器械。



聚二甲基硅氧烷 (PDMS) 常用于医疗器械,因为它无毒且对氧化应激稳定。然而,相对较高的血小板粘附性和通过固化进行化学交联的需要限制了其实用性。在这项研究中,合成了一种生物稳定的基于 PDMS 的聚氨酯脲两性离子磺基甜菜碱 ( PDMS-SB-UU ),可用于制造或涂层血液接触装置,例如导管、人工肺和微流体装置。合成的PDMS-SB-UU的化学结构和物理性质通过1 H-核磁共振( 1 H-NMR)、X射线衍射(XRD)和单轴应力-应变曲线证实。 PDMS-SB-UU体外稳定性经证实对脂肪酶和 30% H 2 O 2持续 8 周,并且与对照 PDMS 相比,PDMS-SB-UU表现出明显更高的对纤维蛋白原吸附和血小板沉积的抵抗力。此外, PDMS-SB-UU分别对全羊血和大鼠血管平滑肌细胞 (rSMC) 没有溶血作用和细胞毒性。由于其软段和硬段具有独特的物理化学特性,PDMS-SB-UU通过静电纺丝成功加工成小直径 (0.80 ± 0.05 mm) 导管,并涂覆在基于 PDMS 和聚丙烯的血液接触生物材料上。
更新日期:2020-09-23
down
wechat
bug