Catalytic hairpin assembly-based electrochemical biosensor with tandem signal amplification for sensitive microRNA assay.,Chemical Communications

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Catalytic hairpin assembly-based electrochemical biosensor with tandem signal amplification for sensitive microRNA assay.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-07-27 , DOI: 10.1039/d0cc04855k
Lin Cui ₁ , Jinghua Zhou ₁ , Xiao-Yun Yang ₂ , Jing Dong ₃ , Xiaolei Wang ₁ , Chun-Yang Zhang ₁

Affiliation

We demonstrate for the first time the construction of a low background electrochemical biosensor with tandem signal amplification for sensitive microRNA assay based on target-activated catalytic hairpin assembly (CHA) of heteroduplex-templated copper nanoparticles. This electrochemical biosensor exhibits high sensitivity, good specificity, single-base mismatch discrimination capability, excellent stability and reproducibility, and it can sensitively detect microRNA in cancer cells.

中文翻译：

基于催化发夹组装的电化学生物传感器，具有串联信号放大功能，用于敏感的microRNA分析。

我们首次展示了基于异源双链模板铜纳米颗粒的靶标活化催化发夹组装（CHA）的敏感microRNA分析的串联信号放大的低背景电化学生物传感器的构建。这种电化学生物传感器具有高灵敏度，良好的特异性，单碱基错配识别能力，出色的稳定性和可重复性，并且可以灵敏地检测癌细胞中的微小RNA。

更新日期：2020-09-01

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