2 型糖尿病患者糖尿病视网膜病变的进展和肾功能下降。,Journal of Diabetes Research

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2 型糖尿病患者糖尿病视网膜病变的进展和肾功能下降。
Journal of Diabetes Research ( IF 3.6 ) Pub Date : 2020-07-27 , DOI: 10.1155/2020/8784139
AJin Cho _{1,

2} , Hayne Cho Park _{1,

2} , Young-Ki Lee _{1,

2} , Young Joo Shin ₃ , So Hyun Bae ₃ , Hakyoung Kim ₃

Affiliation

背景。在韩国的一所大学医院，我们进行了一项回顾性研究，以确定糖尿病视网膜病变 (DR) 进展与 2 型糖尿病肾功能下降之间的关系。方法。我们纳入了 2006 年 8 月至 2014 年 2 月期间在我们的糖尿病诊所随访并接受眼底照相检查的 1527 名 2 型糖尿病患者。DR 由视网膜眼科医生使用综合眼科检查进行评估。结果. 非增殖性 DR (NPDR) 和增殖性 DR (PDR) 的基线患病率分别为 26.5% 和 14.7%。在没有 DR 和 NPDR 的 1303 名患者中，134 名（10.3%）患者进展为 NPDR 或 PDR。进展组的糖尿病病程更长，空腹血糖更高，HbA1c 更高，随访期间 eGFR 下降率≥20%。多变量分析后，eGFR 下降≥20%（优势比 2.553，95% CI 1.219-5.348，)是 NPDR 患者 DR 进展的独立危险因素。结论。肾功能下降与 NPDR 患者的 DR 进展独立相关，这表明应建议对肾功能下降的患者进行 DR 状态调查。

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Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes.

Background. At a university hospital in Korea, we conducted a retrospective study to determine the association of the progression of diabetic retinopathy (DR) with declining renal function in type 2 diabetes. Methods. We included a total of 1527 patients with type 2 diabetes who followed up in our diabetes clinic and underwent fundus photographic examinations from August 2006 to February 2014. DR was assessed by retinal ophthalmologists using comprehensive ophthalmologic examinations. Results. The baseline prevalence of nonproliferative DR (NPDR) and proliferative DR (PDR) was 26.5% and 14.7%, respectively. Among 1303 patients with no DR and NPDR, 134 (10.3%) patients progressed to NPDR or PDR. The progression group had longer duration of diabetes, higher fasting plasma glucose, higher HbA1c, and a higher rate of ≥20% decline in eGFR during the follow-up period. After multivariate analysis, ≥20% decline in eGFR (odds ratio 2.553, 95% CI 1.219-5.348, ) was an independent risk factor for progression of DR in patients with NPDR. Conclusion. Declining renal function was independently associated with DR progression in patients with NPDR, suggesting that investigation of DR status should be recommended for patients with declining renal function.

更新日期：2020-07-27

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