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An insight on medicinal attributes of 1,2,4-triazoles.
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-07-27 , DOI: 10.1016/j.ejmech.2020.112652
Ranjana Aggarwal 1 , Garima Sumran 2
Affiliation  

The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic and anti-inflammatory agents, etc. along with structure-activity relationship. The comprehensive compilation of work carried out in the last decade on 1,2,4-triazole nucleus will provide inevitable scope for researchers for the advancement of novel potential drug candidates having better efficacy and selectivity.



中文翻译:

深入了解 1,2,4-三唑的药用特性。

本综述旨在总结 1,2,4-三唑作为一种新兴的特殊支架的药理特性,作为抗真菌、抗菌、抗癌、抗惊厥、抗结核、抗病毒、抗寄生虫、镇痛和抗炎药物等。具有构效关系。对过去十年在 1,2,4-三唑核上开展的工作进行全面汇编,将为研究人员开发具有更好功效和选择性的新型潜在候选药物提供必然的空间。

更新日期:2020-08-08
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