Near infrared light‐induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol,Journal of Applied Polymer Science

当前位置： X-MOL 学术 › J. Appl. Polym. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Near infrared light‐induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-07-24 , DOI: 10.1002/app.49665
Huy Minh Dao ₁ , Amit Raviraj Pillai ₁ , Rishi Thakkar ₁ , Sanjiv Parajuli ₂ , Esteban Urena‐Benavides ₂ , Seongbong Jo ₁

Affiliation

Light‐sensitive drug delivery systems are considered ideal for applications in the biomedical fields for their ability to release the payload in an on‐demand spatiotemporal controlled manner through the manipulation of the light source. Among the broad radiation spectrum, near infrared (NIR) light is considered advantageous compared to UV and visible light, due to its inherently lower photodamage to normal tissues and deeper penetration to lesion areas. In this study, we report a successful synthesis of a polymer capable of undergoing partial degradation upon irradiation with NIR light by conjugating 10‐N‐carbamoyl linkage methylene blue (MB) moiety, a NIR photocleavable ligand, with polyethylene glycol (PEG). Through effective coupling of MB, a hydrophobic moiety, to the hydrophilic PEG molecule, an amphiphilic polymer was synthesized, as demonstrated by a lowered surface tension (55 mN/m at 0.1% wt/vol). Subsequently, photo‐induced reversal of surface activity associated with self‐assembled structure disruption, was displayed by surface tension measurements, size distribution analysis, and burst release profile of paclitaxel (PTX) from polymeric micelles upon the exposure to NIR irradiation.

中文翻译：

近红外光诱导的基于亚甲基蓝共轭聚乙二醇的聚合物胶束的拆卸

光敏药物输送系统被认为是生物医学领域应用的理想选择，因为它们能够通过操纵光源按时空受控方式释放有效载荷。在宽广的辐射光谱中，近红外（NIR）光被认为比UV和可见光更具优势，因为它固有地对正常组织的光损伤较小，并且对病变区域的穿透性更强。在这项研究中，我们报告了通过共轭10- N可以成功合成能够在NIR光照射下发生部分降解的聚合物的合成方法氨基甲酸酯键亚甲基蓝（MB）部分，一种可近红外裂解的配体，与聚乙二醇（PEG）。通过将疏水部分MB与亲水性PEG分子有效偶联，可以合成两亲性聚合物，这可通过降低表面张力（0.1％wt / vol时为55 mN / m）来证明。随后，通过表面张力测量，尺寸分布分析和紫杉醇（PTX）在暴露于NIR辐照下从聚合物胶束中的爆发释放曲线，显示出与自组装结构破坏相关的表面活性的光诱导逆转。

更新日期：2020-09-28

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南