This study reports an efficient eco-friendly microwave assisted synthesis of 1-(4-(benzothiazol-2-yl)piperazin-1-yl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethanone (4) through the click cyclocondensation of 2-azido-1-(4-(benzo[d]thiazol-2-yl)piperazin-1-yl)ethanone (3) with phenyl acetylene. The synthesis was carried out under optimized copper catalyst copper(II) sulfate pentahydrate/sodium ascorbate, t-BuOH/water (1:1, v/v) to afford the regioselective 1,4-disubstituted 1,2,3-triazole isomer. The reactions were greatly accelerated using microwave irradiation. The new designed 1,2,3-triazole was fully characterizid by IR, NMR, MS spectral data and X-ray diffraction. The crystal structure of 4 demonstrated a conventional chair conformation for the piperazine ring. Interesting Hirshfeld Surface Analysis (HAS) was conducted showing clear agreement with the XRD analysis.

这项研究报告了高效的环保微波辅助合成1-（4-（苯并噻唑-2-基）哌嗪-1-基）-2-（4-苯基-1 H -1,2,3-三唑-1 -基）乙酮（4）通过2-叠氮基-1-（4-（苯并[点击环化缩合d ]噻唑-2-基）哌嗪-1-基）乙酮（3）与苯基乙炔。在优化的铜催化剂下合成五水合硫酸铜（II）五水合/抗坏血酸钠，t- BuOH /水（1：1，v / v），得到区域选择性的1,4-二取代的1,2,3-三唑异构体。使用微波辐射极大地促进了反应。通过IR，NMR，MS光谱数据和X射线衍射对新设计的1,2,3-三唑进行了完全表征。4的晶体结构证明了哌嗪环的常规椅子构型。进行了有趣的Hirshfeld表面分析（HAS），与XRD分析显示出明显的一致性。