ABSTRACT

Cellulose is known as the most abundant natural polymer and ethyl cellulose (EC) is one of its important derivatives. Recently, EC, as a non-toxic and biodegradable polymer, has attracted attention thanks to its unique properties such as oleogel formation, delivery of active component, and film-forming ability in the food and pharmaceutical sectors. EC-based oleogels have great promise for replacing with unhealthy hydrogenated oils in food products. The EC emulgel could be used as a fat replacer in different food and drug formulation and also for encapsulation of active components. EC, as a non-digestable and water-insoluble polymer, forms micro- and nano-particles with unique properties. Accordingly, this paper tries to focus on mechanistic review of different methods for the fabrication of EC-based formulations and micro/nanoparticles with emphasis on recent progress on wide range applications of the water-insoluble polymer. Additionally, different techniques are discussed in this paper including oleogelation, anti-solvent, emulsion, Pickering emulsion, and electrospinning for the preparation of EC-based formulations.

摘要

纤维素被称为最丰富的天然聚合物，乙基纤维素（EC）是其重要的衍生物之一。近年来，EC作为一种无毒且可生物降解的聚合物，由于其独特的特性（如油凝胶形成、活性成分的传递和成膜能力）在食品和制药领域引起了人们的关注。基于 EC 的油凝胶在替代食品中不健康的氢化油方面具有很大的前景。EC 乳剂可用作不同食品和药物配方中的脂肪替代物，也可用于封装活性成分。EC作为一种不易消化且不溶于水的聚合物，可形成具有独特性能的微米和纳米颗粒。因此，本文试图重点对制备基于 EC 的配方和微/纳米颗粒的不同方法进行机械审查，重点介绍水不溶性聚合物广泛应用的最新进展。此外，本文还讨论了不同的技术，包括油凝胶化、反溶剂、乳液、皮克林乳液和静电纺丝，用于制备基于 EC 的配方。