Perfluorocarbon (PFC) nanoemulsions, droplets of fluorous solvent stabilized by surfactants dispersed in water, are simple yet versatile nanomaterials. The orthogonal nature of the fluorous phase promotes the formation of nanoemulsions through a simple, self-assembly process while simultaneously encapsulating fluorous-tagged payloads for various applications. The size, stability, and surface chemistry of PFC nanoemulsions are controlled by the surfactant. Here, we systematically study the effect of the hydrophilic portion of polymer surfactants on PFC nanoemulsions. We find that the hydrophilic block length and identity, the overall polymer hydrophilic/lipophilic balance, and the polymer architecture are all important factors. The ability to modulate these parameters enables control over initial size, stability, payload retention, cellular internalization, and protein adsorption of PFC nanoemulsions. With the insight obtained from this systematic study of polymer amphiphiles stabilizing PFC nanoemulsions, design features required for the optimal material are obtained.

中文翻译：

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聚合物两亲物稳定的全氟化碳纳米乳液的系统研究。

全氟化碳 (PFC) 纳米乳液是由分散在水中的表面活性剂稳定的氟溶剂液滴，是简单但用途广泛的纳米材料。氟相的正交性质通过简单的自组装过程促进纳米乳液的形成，同时封装用于各种应用的氟标记有效负载。PFC 纳米乳液的尺寸、稳定性和表面化学由表面活性剂控制。在这里，我们系统地研究了聚合物表面活性剂的亲水部分对PFC纳米乳液的影响。我们发现亲水嵌段长度和特性、整体聚合物亲水/亲油平衡以及聚合物结构都是重要因素。调节这些参数的能力能够控制 PFC 纳米乳液的初始尺寸、稳定性、有效负载保留、细胞内化和蛋白质吸附。通过对聚合物两亲物稳定 PFC 纳米乳液的系统研究获得的见解，获得了最佳材料所需的设计特征。