Cancer Cell-Targeted Photosensitizer and Therapeutic Protein Co-Delivery Nanoplatform Based on a Metal-Organic Framework for Enhanced Synergistic Photodynamic and Protein Therapy.,ACS Applied Materials & Interfaces

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Cancer Cell-Targeted Photosensitizer and Therapeutic Protein Co-Delivery Nanoplatform Based on a Metal-Organic Framework for Enhanced Synergistic Photodynamic and Protein Therapy.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-07-24 , DOI: 10.1021/acsami.0c09657
Lei Ding _{1,

2} , Xiao Lin ₃ , Ziguo Lin ₂ , Yanni Wu _{1,

2,

4} , Xiaolong Liu _{1,

2,

4} , Jingfeng Liu _{1,

2,

4,

5} , Ming Wu _{1,

2,

4} , Xiaolong Zhang _{1,

2,

4} , Yongyi Zeng _{1,

2,

4,

5}

Affiliation

Efficient and cancer cell-targeted delivery of photosensitizer (PS) and therapeutic protein has great potentiality for improving the anticancer effects. Herein, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, one of the most attractive metal–organic framework materials, were used for coencapsulating the chlorin e6 (Ce6, a potent PS) and cytochrome c (Cyt c, a protein apoptosis inducer); then the nanoparticle was subsequently decorated with the hyaluronic acid (HA) shell to form cancer cell-active targeted nanoplatform (Ce6/Cyt c@ZIF-8/HA). The in vitro and in vivo experiments show the cancer cell targeting capability and pH-responsive decomposition and the release behavior of Ce6/Cyt c@ZIF-8/HA. Upon light irradiation, the released Ce6 produced cytotoxic reactive oxygen species for photodynamic therapy. Meanwhile, the released Cyt c-induced programmed cell death for protein therapy. Furthermore, the Cyt c worked normally under hypoxia conditions and could decompose H₂O₂ to O₂ (with peroxidase-/catalase-like activity), resulting in synergistically improved therapeutic efficiency. These small molecules and protein codelivery nanoplatforms would promote the development of complementary and synergetic modes for biomedical applications.

中文翻译：

基于金属有机框架的癌细胞靶向光敏剂和治疗性蛋白质共递送纳米平台，用于增强协同光动力学和蛋白质治疗。

有效且以癌细胞为目标的光敏剂（PS）和治疗性蛋白质的递送具有改善抗癌作用的巨大潜力。在这里，沸石-咪唑盐骨架8（ZIF-8）纳米颗粒是最有吸引力的金属有机骨架材料之一，用于共包封二氢卟酚e6（Ce6，一种强力PS）和细胞色素c（Cyt c，一种蛋白凋亡诱导剂））; 然后用透明质酸（HA）壳修饰纳米颗粒，形成癌细胞活性靶向纳米平台（Ce6 / Cyt c @ ZIF-8 / HA）。在体外和体内试验表明癌细胞靶向能力和pH响应性分解和的Ce6 /细胞色素的释放行为Ç@ ZIF-8 / HA。在光照射下，释放的Ce6产生细胞毒性的活性氧，用于光动力疗法。同时，释放的Cyt c诱导程序性细胞死亡用于蛋白质治疗。此外，Cyt c在缺氧条件下可以正常工作，并且可以将H ₂ O ₂分解为O ₂（具有过氧化物酶/过氧化氢酶样活性），从而协同提高治疗效率。这些小分子和蛋白质代码传递纳米平台将促进生物医学应用互补和协同模式的发展。

更新日期：2020-07-24

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