First Report for Levodopa Electrocatalytic Oxidation Based on Copper Metal‐Organic Framework (MOF): Application in a Voltammetric Sensor Development for Levodopa in Real Samples,ChemistrySelect

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First Report for Levodopa Electrocatalytic Oxidation Based on Copper Metal‐Organic Framework (MOF): Application in a Voltammetric Sensor Development for Levodopa in Real Samples
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-07-24 , DOI: 10.1002/slct.202001781
Roghaiyeh Asadpour Joghani ₁ , Amir Abbas Rafati ₁ , Javad Ghodsi ₁ , Parnaz Assari ₁ , Azizallah Feizollahi ₁

Affiliation

Levodopa (LD) determination was achieved for the first time by a cooper metal‐organic framework (MOF) based nanocomposite modified electrode. This research describes a simple, sensitive and cost‐effective electrochemical method for the detection of LD in real samples and the laboratory samples. This method is based on LD oxidation on glassy carbon electrode (GCE) surface modified with multi‐walled carbon nanotubes and copper terephthalic acid MOF (MWCNTs/Cu (TPA) MOF) nanocomposite. MOF was synthesized by the hydrothermal method. The synthesized MOF was characterized by Fourier‐transform infrared spectrophotometry (FT‐IR), energy‐dispersive X‐ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM) and X‐ray diffraction (XRD). Electrochemical studies were accomplished by square wave voltammetry (SWV) and cyclic voltammetry (CV). The applied MOF, as a Cu‐containing synthetic peroxidase enzyme, can electrocatalyze oxidation of LD on the electrode surface and in incorporation with MWCNTs illustrated satisfactory synergic electrocatalytical properties which leads to sensitive detection of LD in the human serum sample. Limit of detection (LOD), sensitivity and linear range were 2 nmol L^–1, 2.26 μA/μmol L^–1 and 0.9‐35 μmol L^–1 respectively, which in compared to other enzymatic or non‐enzymatic sensors were completely satisfying. Ultimately, stability, repeatability and reproducibility of as‐prepared sensor were investigated and the results were acceptable.

中文翻译：

基于铜-金属-有机骨架（MOF）的左旋多巴电催化氧化的首次报告：在实际样品中左旋多巴的伏安传感器开发中的应用

左旋多巴（LD）的测定首次通过基于库珀金属有机骨架（MOF）的纳米复合修饰电极完成。这项研究描述了一种用于检测实际样品和实验室样品中LD的简单，灵敏且经济高效的电化学方法。该方法基于用多壁碳纳米管和对苯二甲酸铜MOF（MWCNTs / Cu（TPA）MOF）纳米复合材料改性的玻璃碳电极（GCE）表面上的LD氧化。MOF是通过水热法合成的。通过傅里叶变换红外分光光度法（FT-IR），能量色散X射线光谱法（EDX），场发射扫描电子显微镜（FESEM）和X射线衍射（XRD）对合成的MOF进行了表征。电化学研究是通过方波伏安法（SWV）和循环伏安法（CV）完成的。所应用的MOF作为一种含Cu的合成过氧化物酶，可以电催化电极表面上LD的氧化，并与MWCNT结合使用，显示出令人满意的协同电催化性能，从而可灵敏地检测人血清样品中的LD。检测下限（LOD），灵敏度和线性范围均为2 nmol L^-1，2.26μA/微摩尔大号^-1和0.9-35微摩尔大号^-1其中在相对于其他酶或非酶传感器被完全满足分别。最终，对所制备传感器的稳定性，可重复性和再现性进行了研究，结果令人满意。

更新日期：2020-07-24

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