Mulberry (Morus alba) leaf is traditionally consumed as a functional tea with remedial effects, such as preventing aging‐related diseases. Two similar compounds, quercetin 3‐O‐malonylglucoside, and kaempferol 3‐O‐malonylglucoside, were detected in mulberry leaves and found to be structural recombinant composites of teaghrelin and emoghrelin, two classes of non‐peptidyl compounds functionally identified as analogs of ghrelin. Molecular modeling showed that these two mulberry compounds were able to enter and interact with the ghrelin receptor and theoretical calculation revealed that they were similar to emoghrelin but slightly weaker than teaghrelin in terms of interaction with the receptor. The relatively abundant compound, quercetin 3‐O‐malonylglucoside was subjected to a bioactivity assay, and the result confirmed that it was able to increase the growth hormone secretion of rat anterior pituitary cells. It seems that quercetin 3‐O‐malonylglucoside is also a functional analog of ghrelin and presumably a key ingredient for the anti‐aging activity of mulberry leaves.

中文翻译：

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桑叶 (Morus alba) 中的槲皮素 3-O-丙二酰葡糖苷是生长素释放肽的功能类似物。

桑叶 ( Morus alba ) 叶子传统上作为一种功能性茶食用，具有治疗作用，例如预防与衰老相关的疾病。在桑叶中检测到两种相似的化合物，槲皮素 3 - O-丙二酰葡糖苷和山奈酚 3 - O-丙二酰葡糖苷，发现它们是茶生长素释放肽和 emoghrelin 的结构重组复合物，这两类非肽基化合物在功能上被鉴定为生长素释放肽的类似物。分子模型表明，这两种桑树化合物能够进入ghrelin受体并与之相互作用，理论计算表明它们与emoghrelin相似，但在与受体的相互作用方面略弱于teaghrelin。相对丰富的化合物，槲皮素 3- O对丙二酰葡萄糖苷进行生物活性测定，结果证实它能够增加大鼠垂体前叶细胞的生长激素分泌。槲皮素 3- O-丙二酰葡糖苷似乎也是生长素释放肽的功能类似物，可能是桑叶抗衰老活性的关键成分。