Local bacterial infection remains an increasingly severe threat to human health worldwide, and infection control is still a challenging task in clinics. Systemic administration of antibiotics usually causes adverse effects and bacterial resistance. Multi-functions hydrogel without drug-resistance is highly desired. Herein, we first synthesize antibacterial carbon quantum dots (CQD_AG) with low-drug resistance using gentamicin sulfate and diammonium citrate as precursors. Then carboxymethyl chitosan (CMCS)-mixed CQD_AG is reacted with oxidized dextran (ODex) through the Schiff base linkage to yield hydrogel network. Hydrogel decorated with 2 mg/mL CQD_AG (CQD_AG2-hydrogel) shows multi-functions including inherent self-healing, injectable, stretchable, compressive property, pH-dependent release of CQD_AG and especially inhibiting biofilm formation, which are beneficial for treating bacterial infections. Besides, it is important that CQD_AG2-hydrogel exhibits good cytocompatibility while sterilizing. In vivo antibacterial and wound healing evaluations demonstrate CQD_AG2-hydrogel have the effect of anti-inflammation and promoting wound repair, which is manifested in wound healing rate, granulation tissue thickness and collagen disposition. The result indicates that the CQD_AG2-hydrogel is excellent candidate for full-thickness skin wound healing.

局部细菌感染仍然是全球范围内对人类健康日益严重的威胁，而感染控制仍然是诊所的一项艰巨任务。全身性使用抗生素通常会引起不良反应和细菌耐药性。高度希望没有耐药性的多功能水凝胶。在此，我们首先以硫酸庆大霉素和柠檬酸二铵为前体合成具有低耐药性的抗菌碳量子点（CQD _AG）。然后，将羧甲基壳聚糖（CMCS）混合的CQD _AG通过Schiff碱键与氧化葡聚糖（ODex）反应，生成水凝胶网络。用2 mg / mL CQD _AG（CQD _AG2）装饰的水凝胶-水凝胶）具有多种功能，包括固有的自我修复，可注射，可拉伸，压缩性质，pH依赖的CQD _AG释放，尤其是抑制生物膜形成，这对于治疗细菌感染非常有益。此外，重要的是，CQD _AG2-水凝胶在灭菌时表现出良好的细胞相容性。体内抗菌和伤口愈合评估表明，CQD _AG2-水凝胶具有抗发炎和促进伤口修复的作用，表现为伤口愈合速度，肉芽组织厚度和胶原蛋白分布。结果表明，CQD _AG2-水凝胶是全层皮肤伤口愈合的极佳候选者。