The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression,International Journal of Biological Macromolecules

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The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2020-07-22 , DOI: 10.1016/j.ijbiomac.2020.07.191
Yang Liu ₁ , Xinjie Yu ₂ , Jianxin Zhao ₁ , Hao Zhang ₃ , Qixiao Zhai ₄ , Wei Chen ₅

Affiliation

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Hwa Chong Institution (College), 661 Bukit Timah Road, Singapore 269734, Singapore.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.

MUC2 mucin is an important secretory protein found in the human gut. Recent studies indicated that MUC2 mucin plays a role in the protection of gut barrier, the regulation of microbiome homeostasis and the prevention of diseases. In this review, the physiological properties of MUC2 mucin and its interactions with the intestinal microbiome are firstly discussed. Its roles in intestinal diseases including inflammatory bowel disease, colorectal cancer and parasitic infections are concluded. We also reviewed dietary components known to have modulative effects on MUC2 mucin expression, such as polysaccharides, amino acids and polyphenols.

中文翻译：

MUC2 粘蛋白在肠道稳态中的作用以及膳食成分对 MUC2 表达的影响

MUC2 粘蛋白是在人体肠道中发现的一种重要的分泌蛋白。最近的研究表明，MUC2 粘蛋白在保护肠道屏障、调节微生物组稳态和预防疾病方面发挥作用。本文首先讨论了 MUC2 粘蛋白的生理特性及其与肠道微生物组的相互作用。总结了它在肠道疾病中的作用，包括炎症性肠病、结直肠癌和寄生虫感染。我们还回顾了已知对 MUC2 粘蛋白表达有调节作用的膳食成分，例如多糖、氨基酸和多酚。

更新日期：2020-07-22

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