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Quinolin-8-yl Formate: A New Option for Small-Scale Carbonylation Reactions in Microwave Reactors
Synlett ( IF 1.7 ) Pub Date : 2020-07-17 , DOI: 10.1055/s-0040-1707187 J. Craig Ruble 1 , Christopher J. Maddocks 2 , Sivakumar V. Aathimanikandan 3 , Jeffery Richardson 2
Synlett ( IF 1.7 ) Pub Date : 2020-07-17 , DOI: 10.1055/s-0040-1707187 J. Craig Ruble 1 , Christopher J. Maddocks 2 , Sivakumar V. Aathimanikandan 3 , Jeffery Richardson 2
Affiliation
A convenient procedure for conducting small-scale carbonylations of aryl or benzyl halides in a microwave reactor by using quinolin-8-yl formate is described. The resulting 8-acyloxyquinolines were shown to be more reactive than phenyl esters in acyl-transfer reactions, and their utility for the production of esters and amides was demonstrated.
中文翻译:
喹啉-8-基甲酸酯:微波反应器中小规模羰基化反应的新选择
描述了在微波反应器中通过使用甲酸喹啉-8-基酯进行芳基或苄基卤的小规模羰基化的方便程序。所得的 8-酰氧基喹啉在酰基转移反应中比苯基酯更具反应性,并且证明了它们在酯和酰胺生产中的效用。
更新日期:2020-07-17
中文翻译:
喹啉-8-基甲酸酯:微波反应器中小规模羰基化反应的新选择
描述了在微波反应器中通过使用甲酸喹啉-8-基酯进行芳基或苄基卤的小规模羰基化的方便程序。所得的 8-酰氧基喹啉在酰基转移反应中比苯基酯更具反应性,并且证明了它们在酯和酰胺生产中的效用。