During injury or diseased condition, wound dressing fails to properly integrate or repair the tissue and restore its function due to various factors like poor bioavailability, systemic delivery of hydrophobic drugs and elevated levels of reactive oxygen species. Here, we fabricated a novel nano-hybrid hydrogel system, based-on gelatin and oxidized dextran, embedded with nano-formulation of curcumin and cerium oxide, dispersed by physical interaction within the hydrogel. The curcumin was entrapped in amphiphilic alkylated-dextran nanoparticles to enhance its bioavailability and release at the injured site while cerium oxide nanoparticles were used without any additional processing. The hydrogel was characterized for various properties and demonstrated a controlled and prolonged drug release (∼63 % in 108 h), accelerated cell migration besides providing a highly significant antioxidant and in-vivo anti-inflammatory activity (∼39 %). The preliminary study suggests that this hybrid system can significantly promote wound healing and the potential to become an ideal wound dressing.

在受伤或患病期间，由于各种因素，例如生物利用度差、疏水性药物的全身递送和活性氧水平升高，伤口敷料无法正确整合或修复组织并恢复其功能。在这里，我们制造了一种基于明胶和氧化葡聚糖的新型纳米混合水凝胶系统，嵌入了姜黄素和氧化铈的纳米配方，通过物理相互作用分散在水凝胶中。姜黄素被包裹在两亲性烷基化葡聚糖纳米粒子中，以提高其生物利用度并在受伤部位释放，而氧化铈纳米粒子则无需任何额外处理即可使用。该水凝胶具有多种特性，并表现出受控和延长的药物释放（108 小时内~63 %），除了提供非常显着的抗氧化和体内抗炎活性（~39%）之外，还加速了细胞迁移。初步研究表明，这种混合系统可以显着促进伤口愈合，并有可能成为理想的伤口敷料。