Nile Red and Nile Blue: Applications and Syntheses of Structural Analogues,Chemistry - A European Journal

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Nile Red and Nile Blue: Applications and Syntheses of Structural Analogues
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2016-07-13 , DOI: 10.1002/chem.201601570
Vincent Martinez ₁ , Maged Henary ₁

Affiliation

Nile red and Nile blue are highly fluorescent and photostable organic dyes from the benzo[a]phenoxazine family. They have been used as histological stains for imaging lysosomes and lipids in vitro. The dyes’ high quantum yields and solvent‐dependent optical properties make them ideal scaffolds for the development of pH probes and local polarity indicators. Reviews of the literature in this area are scarce with only one review ever published in 2006. It has been 10 years since and the field has evolved. This review aims to expand upon topics covered by the previous reviewers and to report on recent advances in the literature. As authors, we hope to convey a sense of scope and to spark renewed interest in this useful niche of dye chemistry.

中文翻译：

尼罗河红和尼罗河蓝：结构类似物的应用和合成

尼罗红和尼罗蓝是来自苯并[ a ]吩恶嗪家族的高度荧光且耐光的有机染料。它们已被用作组织学染色剂，用于在体外对溶酶体和脂质成像。染料的高量子产率和取决于溶剂的光学特性使其成为开发pH探针和局部极性指示剂的理想支架。该领域的文献评论稀少，2006年仅发表过一篇评论。距今已有10年，并且该领域已经发展。这篇综述旨在扩展以前的综述者所涵盖的主题，并报告文献方面的最新进展。作为作者，我们希望传达一种范围感，并引起人们对这种有用的染料化学领域的新兴趣。

更新日期：2016-07-13

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