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1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors.
ACS Omega ( IF 3.7 ) Pub Date : 2020-07-15 , DOI: 10.1021/acsomega.0c02466 Marianne B Haarr 1 , Óscar Lopéz 2 , Ljupcho Pejov 1 , José G Fernández-Bolaños 2 , Emil Lindbäck 1 , Magne O Sydnes 1
ACS Omega ( IF 3.7 ) Pub Date : 2020-07-15 , DOI: 10.1021/acsomega.0c02466 Marianne B Haarr 1 , Óscar Lopéz 2 , Ljupcho Pejov 1 , José G Fernández-Bolaños 2 , Emil Lindbäck 1 , Magne O Sydnes 1
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The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).
中文翻译：
1,4-二甲氧基-1,4-亚氨基-d-阿拉伯糖醇（DAB）类似物，具有酰肼基酰亚胺部分作为有效的和选择性的α-甘露糖苷酶抑制剂。
2克多羟基化的吡咯烷的作为合成1,4-二脱氧-1,4-亚氨基d -arabinitol（DAB）类似物带有酰肼部分进行说明。DAB类似物在亚微摩尔浓度范围（K i值范围从0.23至1.4μM）中充当α-甘露糖苷酶的选择性抑制剂。
更新日期：2020-07-28
中文翻译：
1,4-二甲氧基-1,4-亚氨基-d-阿拉伯糖醇（DAB）类似物，具有酰肼基酰亚胺部分作为有效的和选择性的α-甘露糖苷酶抑制剂。
2克多羟基化的吡咯烷的作为合成1,4-二脱氧-1,4-亚氨基d -arabinitol（DAB）类似物带有酰肼部分进行说明。DAB类似物在亚微摩尔浓度范围（K i值范围从0.23至1.4μM）中充当α-甘露糖苷酶的选择性抑制剂。
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